CPX may refer to:
- Benjamín Rivera Noriega Airport (IATA code), Puerto Rico
- 8-Cyclopentyl-1,3-dimethylxanthine, a drug
- Ciclopirox, a antifungal drug
- Clinical performance exam, formally objective structured clinical examination, a prerequisite to working in various health care fields
- Clinopyroxene, monoclinic pyroxene, an igneous and metamorphic mineral
- The Centre for Public Christianity (CPX) is a not-for-profit media company that offers a Christian perspective on contemporary life.
- Control Panel eXtension modules of Atari ST computers
- CPX Test; Cardiopulmonary Exercise Test, or Cardiac stress test
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