Cleavage and polyadenylation specificity factor subunit 2 is a protein that in humans is encoded by the CPSF2 gene.[5][6][7] This protein is a subunit of the cleavage and polyadenylation specificity factor (CPSF) complex which plays a key role in pre-mRNA 3' end processing and polyadenylation.[8] The CPSF2 protein connects the two subunits of the complex, mCF and mPSF.[8] Its structure contributes both to the stability of the subunits interaction and to the flexibility of the complex necessary for function.[9] This protein has been identified as an essential subunit of the complex as certain mutations in the region inhibit CPSF complex formation.[9]

PDB-6V4X. CPSF2 protein highlighted within the CPSF complex. CPSF2 is rainbow colored. Other subunits of the complex are represented by solid colors.
CPSF2
Identifiers
AliasesCPSF2, CPSF100, cleavage and polyadenylation specific factor 2
External IDsOMIM: 606028; MGI: 1861601; HomoloGene: 6460; GeneCards: CPSF2; OMA:CPSF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017437
NM_001322270
NM_001322271
NM_001322272

NM_016856

RefSeq (protein)

NP_001309199
NP_001309200
NP_001309201
NP_059133

NP_058552

Location (UCSC)Chr 14: 92.12 – 92.17 MbChr 12: 101.94 – 101.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165934Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041781Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jenny A, Hauri HP, Keller W (Dec 1994). "Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit". Mol Cell Biol. 14 (12): 8183–90. doi:10.1128/MCB.14.12.8183. PMC 359357. PMID 7969155.
  6. ^ Samiotaki M, Balatsos NA, Courtis N, Tsiapalis CM (Jan 2001). "Assignment of the 100-kDa subunit of cleavage and polyadenylation specificity factor (CPSF2) to human chromosome 14q31.3 by radiation hybrid mapping". Cytogenet Cell Genet. 90 (3–4): 328–9. doi:10.1159/000056798. PMID 11124543. S2CID 84335742.
  7. ^ "Entrez Gene: CPSF2 cleavage and polyadenylation specific factor 2, 100kDa".
  8. ^ a b "Human Gene CPSF2 (ENST00000298875.9) from GENCODE V43". genome.ucsc.edu. Retrieved 2023-03-05.
  9. ^ a b Zhang Y, Sun Y, Shi Y, Walz T, Tong L (2020-02-20). "Structural Insights into the Human Pre-mRNA 3′-End Processing Machinery". Molecular Cell. 77 (4): 800–809.e6. doi:10.1016/j.molcel.2019.11.005. ISSN 1097-2765. PMC 7036032. PMID 31810758.
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Further reading

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