Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene.[5][6]

COG3
Identifiers
AliasesCOG3, SEC34, component of oligomeric golgi complex 3
External IDsOMIM: 606975; MGI: 2450151; HomoloGene: 5854; GeneCards: COG3; OMA:COG3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204476
NM_031431

NM_177381

RefSeq (protein)

NP_113619

n/a

Location (UCSC)Chr 13: 45.46 – 45.54 MbChr 14: 75.94 – 75.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene has similarity to a yeast protein. It seems to be part of a peripheral membrane protein complex localized on cis/medial Golgi cisternae where it may participate in tethering intra-Golgi transport vesicles.[6]

Interactions

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COG3 has been shown to interact with COG2[7] and COG1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136152Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034893Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (April 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". The Journal of Cell Biology. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297. PMID 11980916.
  6. ^ a b "Entrez Gene: COG3 component of oligomeric golgi complex 3".
  7. ^ a b Loh E, Hong W (June 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp". The Journal of Biological Chemistry. 277 (24): 21955–61. doi:10.1074/jbc.M202326200. PMID 11929878.
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Further reading

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