Cyclic nucleotide-gated channel alpha 2

Cyclic nucleotide gated channel alpha 2, also known as CNGA2, is a human gene encoding an ion channel protein.

CNGA2
Identifiers
Aliases	CNGA2, CNCA, CNCA1, CNG2, OCNC1, OCNCALPHA, OCNCa, Cyclic nucleotide-gated channel alpha 2, cyclic nucleotide gated channel alpha 2, cyclic nucleotide gated channel subunit alpha 2
External IDs	OMIM: 300338; MGI: 108040; HomoloGene: 32022; GeneCards: CNGA2; OMA:CNGA2 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 151,734,746 bp End 151,745,564 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A7.3 Start 71,035,455 bp End 71,053,824 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis Top expressed in olfactory epithelium urethra embryo secondary oocyte zygote primary oocyte entorhinal cortex central gray substance of midbrain superior frontal gyrus thymus More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding cAMP binding calmodulin binding ion channel activity voltage-gated potassium channel activity intracellular cAMP-activated cation channel activity intracellular cGMP-activated cation channel activity cGMP binding Cellular component integral component of membrane membrane Golgi membrane ciliary membrane Golgi-associated vesicle membrane integral component of plasma membrane Biological process response to stimulus regulation of membrane potential ion transport sensory perception of smell ion transmembrane transport transmembrane transport potassium ion transmembrane transport cation transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1260 12789 Ensembl ENSG00000183862 ENSMUSG00000005864 UniProt Q16280 Q62398 RefSeq (mRNA) NM_005140 NM_007724 RefSeq (protein) NP_005131 NP_031750 Location (UCSC) Chr X: 151.73 – 151.75 Mb Chr X: 71.04 – 71.05 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

See also

• Cyclic nucleotide-gated ion channel

Further reading

• Trudeau MC, Zagotta WN (2003). "Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels". J. Biol. Chem. 278 (21): 18705–8. doi:10.1074/jbc.R300001200. PMID 12626507.
• Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol. Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
• Distler M, Biel M, Flockerzi V, Hofmann F (1995). "Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells". Neuropharmacology. 33 (11): 1275–82. doi:10.1016/0028-3908(94)90027-2. PMID 7532814. S2CID 35784152.
• Finn JT, Krautwurst D, Schroeder JE, et al. (1998). "Functional co-assembly among subunits of cyclic-nucleotide-activated, nonselective cation channels, and across species from nematode to human". Biophys. J. 74 (3): 1333–45. Bibcode:1998BpJ....74.1333F. doi:10.1016/S0006-3495(98)77846-4. PMC 1299480. PMID 9512030.
• Sautter A, Zong X, Hofmann F, Biel M (1998). "An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4696–701. Bibcode:1998PNAS...95.4696S. doi:10.1073/pnas.95.8.4696. PMC 22553. PMID 9539801.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yoo D, Flagg TP, Olsen O, et al. (2004). "Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions". J. Biol. Chem. 279 (8): 6863–73. doi:10.1074/jbc.M311599200. PMID 14604981.
• Cheng KT, Chan FL, Huang Y, et al. (2004). "Expression of olfactory-type cyclic nucleotide-gated channel (CNGA2) in vascular tissues". Histochem. Cell Biol. 120 (6): 475–81. doi:10.1007/s00418-003-0596-2. PMID 14618336. S2CID 9726100.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Qu W, Moorhouse AJ, Chandra M, et al. (2006). "A single P-loop glutamate point mutation to either lysine or arginine switches the cation-anion selectivity of the CNGA2 channel". J. Gen. Physiol. 127 (4): 375–89. doi:10.1085/jgp.200509378. PMC 2151509. PMID 16533895.

External links

• CNGA2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.