FCGR2A

(Redirected from CD32A)

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.[5][6]

FCGR2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesFCGR2A, CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, IGFR2, Fc fragment of IgG receptor IIa, FcgammaRIIa, Fc gamma receptor IIa
External IDsOMIM: 146790; MGI: 95500; HomoloGene: 47936; GeneCards: FCGR2A; OMA:FCGR2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001136219
NM_021642
NM_001375296
NM_001375297

NM_010188
NM_001356511

RefSeq (protein)

NP_001129691
NP_067674
NP_001362225
NP_001362226

n/a

Location (UCSC)Chr 1: 161.51 – 161.52 MbChr 1: 170.88 – 170.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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FCGR2A has been shown to interact with PIK3R1[7][8] and Syk.[8][9]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143226Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059498Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (June 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. Bibcode:1990Sci...248..732Q. doi:10.1126/science.2139735. PMID 2139735.
  6. ^ "Entrez Gene: FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)".
  7. ^ Chacko, G W; Brandt J T; Coggeshall K M; Anderson C L (May 1996). "Phosphoinositide 3-kinase and p72syk noncovalently associate with the low affinity Fc gamma receptor on human platelets through an immunoreceptor tyrosine-based activation motif. Reconstitution with synthetic phosphopeptides". J. Biol. Chem. 271 (18): 10775–81. doi:10.1074/jbc.271.18.10775. ISSN 0021-9258. PMID 8631888.
  8. ^ a b Ibarrola, I; Vossebeld P J; Homburg C H; Thelen M; Roos D; Verhoeven A J (July 1997). "Influence of tyrosine phosphorylation on protein interaction with FcgammaRIIa". Biochim. Biophys. Acta. 1357 (3): 348–58. doi:10.1016/S0167-4889(97)00034-7. ISSN 0006-3002. PMID 9268059.
  9. ^ Kim, M K; Pan X Q; Huang Z Y; Hunter S; Hwang P H; Indik Z K; Schreiber A D (January 2001). "Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis". Clin. Immunol. 98 (1): 125–32. doi:10.1006/clim.2000.4955. ISSN 1521-6616. PMID 11141335.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.