C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene.[5]

CCR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCCR1, CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1, C-C motif chemokine receptor 1
External IDsOMIM: 601159; MGI: 104618; HomoloGene: 20344; GeneCards: CCR1; OMA:CCR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001295

NM_009912

RefSeq (protein)

NP_001286

NP_034042

Location (UCSC)Chr 3: 46.2 – 46.21 MbChr 9: 123.76 – 123.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CCR1 has also recently been designated CD191 (cluster of differentiation 191).

Function

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This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). Chemokines and their receptors, which mediate signal transduction, are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on chromosome 3p.[6]

Interactions

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CCR1 has been shown to interact with CCL5.[7][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163823Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025804Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (February 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor". Cell. 72 (3): 415–25. doi:10.1016/0092-8674(93)90118-A. PMID 7679328. S2CID 38479816.
  6. ^ "Entrez Gene: CCR1 chemokine (C-C motif) receptor 1".
  7. ^ Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001). "Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils". European Journal of Immunology. 31 (7): 2170–8. doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D. PMID 11449371.
  8. ^ Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN (April 2001). "The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity". The Journal of Biological Chemistry. 276 (14): 10620–6. doi:10.1074/jbc.M010867200. PMID 11116158.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.