CFLAR

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called c-FLIP (FLICE-like inhibitory protein).

CFLAR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3H11, 3H13, 2N5R
Identifiers
Aliases	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP
External IDs	OMIM: 603599; MGI: 1336166; HomoloGene: 7652; GeneCards: CFLAR; OMA:CFLAR - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q33.1 Start 201,116,154 bp End 201,176,687 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C1.3|1 29.16 cM Start 58,750,667 bp End 58,798,043 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung apex of heart upper lobe of left lung right auricle left ventricle epithelium of colon blood granulocyte gastrocnemius muscle bone marrow cells Top expressed in granulocyte right kidney ascending aorta aortic valve proximal tubule right lung right lung lobe ciliary body thymus lateral recess More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity protein binding cysteine-type endopeptidase activity involved in execution phase of apoptosis enzyme activator activity cysteine-type endopeptidase activity peptidase activator activity protein heterodimerization activity protease binding death receptor binding protein-containing complex binding cysteine-type endopeptidase activity involved in apoptotic process Cellular component cytosol CD95 death-inducing signaling complex ripoptosome death-inducing signaling complex membrane raft cytoplasm Biological process regulation of apoptotic process execution phase of apoptosis negative regulation of apoptotic process proteolysis positive regulation of I-kappaB kinase/NF-kappaB signaling regulation of necroptotic process regulation of extrinsic apoptotic signaling pathway via death domain receptors viral process apoptotic process positive regulation of catalytic activity response to hypoxia negative regulation of cardiac muscle cell apoptotic process positive regulation of neuron projection development cellular response to insulin stimulus response to testosterone positive regulation of ERK1 and ERK2 cascade cellular response to epidermal growth factor stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to dexamethasone stimulus cellular response to nitric oxide positive regulation of glomerular mesangial cell proliferation positive regulation of extracellular matrix organization negative regulation of reactive oxygen species biosynthetic process negative regulation of cellular response to transforming growth factor beta stimulus negative regulation of hepatocyte apoptotic process negative regulation of epithelial cell apoptotic process positive regulation of hepatocyte proliferation negative regulation of extrinsic apoptotic signaling pathway via death domain receptors skeletal muscle tissue development positive regulation of peptidase activity skeletal muscle atrophy regulation of skeletal muscle satellite cell proliferation skeletal myofibril assembly negative regulation of cysteine-type endopeptidase activity involved in apoptotic process skeletal muscle tissue regeneration positive regulation of NF-kappaB transcription factor activity negative regulation of necroptotic process negative regulation of myoblast fusion negative regulation of extrinsic apoptotic signaling pathway response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8837 12633 Ensembl ENSG00000003402 ENSMUSG00000026031 UniProt O15519 O35732 RefSeq (mRNA) NM_001127183 NM_001127184 NM_001202515 NM_001202516 NM_001202517 NM_001202518 NM_001202519 NM_001308042 NM_001308043 NM_003879 NM_001351590 NM_001351591 NM_001351592 NM_001351593 NM_001351594 NM_001289704 NM_001293804 NM_001293805 NM_009805 NM_207653 NM_001355056 RefSeq (protein) NP_001120655 NP_001120656 NP_001189444 NP_001189445 NP_001189446 NP_001189447 NP_001189448 NP_001294971 NP_001294972 NP_003870 NP_001338519 NP_001338520 NP_001338521 NP_001338522 NP_001338523 NP_001276633 NP_001280733 NP_001280734 NP_033935 NP_997536 NP_001341985 Location (UCSC) Chr 2: 201.12 – 201.18 Mb Chr 1: 58.75 – 58.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Abe K, Kurakin A, Mohseni-Maybodi M, et al. (2001). "The complexity of TNF-related apoptosis-inducing ligand". Ann. N. Y. Acad. Sci. 926 (1): 52–63. doi:10.1111/j.1749-6632.2000.tb05598.x. PMID 11193041. S2CID 45991330.
• Dutton A, Young LS, Murray PG (2006). "The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer". Expert Opin. Ther. Targets. 10 (1): 27–35. doi:10.1517/14728222.10.1.27. PMID 16441226. S2CID 45292123.

External links

• Human CFLAR genome location and CFLAR gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: O15519 (CASP8 and FADD-like apoptosis regulator) at the PDBe-KB.