CADM3

Cell adhesion molecule 3 is a protein that in humans is encoded by the CADM3 gene.

CADM3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z9M
Identifiers
Aliases	CADM3, BIgR, IGSF4B, NECL1, Necl-1, TSLL1, synCAM3, cell adhesion molecule 3, CMT2FF
External IDs	OMIM: 609743; MGI: 2137858; HomoloGene: 10919; GeneCards: CADM3; OMA:CADM3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.2 Start 159,171,609 bp End 159,203,313 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H3 Start 173,160,825 bp End 173,195,261 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum right frontal lobe tibial nerve anterior cingulate cortex nucleus accumbens Brodmann area 9 prefrontal cortex sural nerve amygdala Top expressed in cerebellar cortex neural layer of retina superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell piriform cortex lobe of cerebellum cerebellar vermis motor neuron sciatic nerve More reference expression data BioGPS n/a
Gene ontology Molecular function signaling receptor binding protein homodimerization activity cell adhesion molecule binding Cellular component integral component of membrane cell junction plasma membrane integral component of plasma membrane membrane cell-cell junction parallel fiber to Purkinje cell synapse integral component of presynaptic membrane Biological process protein localization heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion cell recognition adherens junction organization homophilic cell adhesion via plasma membrane adhesion molecules Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57863 94332 Ensembl ENSG00000162706 ENSMUSG00000005338 UniProt Q8N126 Q99N28 RefSeq (mRNA) NM_021189 NM_001127173 NM_001346510 NM_053199 RefSeq (protein) NP_001120645 NP_001333439 NP_067012 NP_444429 Location (UCSC) Chr 1: 159.17 – 159.2 Mb Chr 1: 173.16 – 173.2 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005).

External links

• Human CADM3 genome location and CADM3 gene details page in the UCSC Genome Browser.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shingai T, Ikeda W, Kakunaga S, et al. (2003). "Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells". J. Biol. Chem. 278 (37): 35421–7. doi:10.1074/jbc.M305387200. PMID 12826663.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Fukami T, Satoh H, Williams YN, et al. (2004). "Isolation of the mouse Tsll1 and Tsll2 genes, orthologues of the human TSLC1-like genes 1 and 2 (TSLL1 and TSLL2)". Gene. 323: 11–8. doi:10.1016/j.gene.2003.09.018. PMID 14659875.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Kakunaga S, Ikeda W, Itoh S, et al. (2005). "Nectin-like molecule-1/TSLL1/SynCAM3: a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule localizing at non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes". J. Cell Sci. 118 (Pt 6): 1267–77. doi:10.1242/jcs.01656. PMID 15741237. S2CID 18949720.
• Zhou Y, Du G, Hu X, et al. (2005). "Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane". Biochim. Biophys. Acta. 1669 (2): 142–54. doi:10.1016/j.bbamem.2005.01.013. PMID 15893517.
• Dong X, Xu F, Gong Y, et al. (2006). "Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule". J. Biol. Chem. 281 (15): 10610–7. doi:10.1074/jbc.M513459200. PMID 16467305.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.