tRNA-splicing endonuclease subunit Sen15 is an enzyme that in humans is encoded by the TSEN15 gene .[ 5] [ 6] [ 7]
tRNA splicing is a fundamental process for cell growth and division. SEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns , the first step in tRNA splicing (Paushkin et al., 2004).[supplied by OMIM][ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000198860 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014980 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Sood R, Bonner TI, Makalowska I, Stephan DA, Robbins CM, Connors TD, et al. (April 2001). "Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus" . Genomics . 73 (2): 211–22. doi :10.1006/geno.2001.6500 . PMID 11318611 . ^ Song J, Markley JL (February 2007). "Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold" . Journal of Molecular Biology . 366 (1): 155–64. doi :10.1016/j.jmb.2006.11.024 . PMC 1865571 PMID 17166513 . ^ a b "Entrez Gene: C1orf19 chromosome 1 open reading frame 19" .^ Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (April 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation" . Cell . 117 (3): 311–21. doi :10.1016/S0092-8674(04)00342-3 PMID 15109492 . S2CID 16049289 .
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway" . Genome Research . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation" . Genome Research . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Paushkin SV, Patel M, Furia BS, Peltz SW, Trotta CR (April 2004). "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation" . Cell . 117 (3): 311–21. doi :10.1016/S0092-8674(04)00342-3 PMID 15109492 . S2CID 16049289 .
