Unconventional prefoldin RPB5 interactor, also called URI1, is a protein that in humans is encoded by the URI1 gene.[5][6][7]

URI1
Identifiers
AliasesURI1, C19orf2, NNX3, PPP1R19, RMP, URI, URI1 prefoldin-like chaperone, prefoldin like chaperone, URI1 prefoldin like chaperone
External IDsOMIM: 603494; MGI: 1342294; HomoloGene: 2813; GeneCards: URI1; OMA:URI1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252641
NM_003796
NM_134447

NM_011274

RefSeq (protein)

NP_001239570
NP_003787

NP_035404

Location (UCSC)Chr 19: 29.92 – 30.02 MbChr 7: 37.66 – 37.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[7]

Interactions

edit

URI1 has been shown to interact with DMAP1[8] and STAP1.[9]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105176Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030421Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Van Leuven F, Torrekens S, Moechars D, Hilliker C, Buellens M, Bollen M, Delabie J (Feb 1999). "Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease". Genomics. 54 (3): 511–20. doi:10.1006/geno.1998.5609. PMID 9878255.
  6. ^ Dorjsuren D, Lin Y, Wei W, Yamashita T, Nomura T, Hayashi N, Murakami S (Dec 1998). "RMP, a Novel RNA Polymerase II Subunit 5-Interacting Protein, Counteracts Transactivation by Hepatitis B Virus X Protein". Mol Cell Biol. 18 (12): 7546–55. doi:10.1128/mcb.18.12.7546. PMC 109335. PMID 9819440.
  7. ^ a b "Entrez Gene: C19orf2 chromosome 19 open reading frame 2".
  8. ^ Delgermaa L, Hayashi N, Dorjsuren D, Nomura T, Thuy le TT, Murakami S (Oct 2004). "Subcellular Localization of RPB5-Mediating Protein and Its Putative Functional Partner". Mol. Cell. Biol. 24 (19): 8556–66. CiteSeerX 10.1.1.605.6435. doi:10.1128/MCB.24.19.8556-8566.2004. PMC 516735. PMID 15367675.
  9. ^ Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W (Nov 2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. Bibcode:2003Sci...302.1208G. doi:10.1126/science.1088401. PMID 14615539. S2CID 26836888.


edit

Further reading

edit