Two separate types of diesel locomotive operating in Great Britain have been given the TOPS classification Class 21.
- British Rail Class 21 (NBL) - a class of 58 diesel-electric locomotives produced by the North British Locomotive Company from 1958-1960.
- British Rail Class 21 (MaK) - a group of diesel-hydraulic locomotives produced by MaK/Vossloh and used on the Channel Tunnel Rail Link.
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