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Binospirone (MDL-73,005-EF) is a drug which acts as a partial agonist at 5-HT1A somatodendritic autoreceptors but as an antagonist at postsynaptic 5-HT1A receptors.[1] It has anxiolytic effects.[2]

Binospirone
Binospirone.svg
Binospirone 3D.gif
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC20H26N2O4
Molar mass358.431 g/mol g·mol−1
3D model (JSmol)
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SynthesisEdit

 
Binospirone synthesis: EP0236930 

See alsoEdit

ReferencesEdit

  1. ^ Bertrand, F; Lehmann, O; Galani, R; Lazarus, C; Jeltsch, H; Cassel, JC (2001). "Effects of MDL 73005 on water-maze performances and locomotor activity in scopolamine-treated rats". Pharmacology Biochemistry and Behavior. 68 (4): 647–60. doi:10.1016/S0091-3057(01)00448-8. PMID 11526961.
  2. ^ Moser, PC; Tricklebank, MD; Middlemiss, DN; Mir, AK; Hibert, MF; Fozard, JR (1990). "Characterization of MDL 73005EF as a 5-HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8-OH-DPAT and diazepam". British Journal of Pharmacology. 99 (2): 343–9. doi:10.1111/j.1476-5381.1990.tb14706.x. PMC 1917389. PMID 1970269.