Bing Liu (scientist)

Bing Liu (1982 – May 2, 2020) was a Chinese coronavirus researcher living and researching in the United States.[1] He was a Research Assistant Professor of Computational & Systems Biology Department at the University of Pittsburgh School of Medicine.[1] He was 37 years old at the time of his death, in which he was shot dead in his home. The case received American and Chinese media coverage.[1]

DeathEdit

Liu was found dead at his home on May 2, 2020.[1] His work on coronaviruses led to speculation that his murder was related to his work, but Pittsburgh Police said that he was shot as a result of a murder-suicide.[1] The gunman was 46-year-old software engineer Hao Gu.[1] The police said that the murder was the result of a dispute over an intimate partner and that after murdering Bing Liu the gunman had gone back to his car and shot himself.[1]

WorksEdit

Books
  • B Liu. Computational Modeling of Biological Pathways: Probabilistic Approximation and Analysis Techniques. LAP LAMBERT Academic Publishing, ISBN 3847372114, Jan 2012. (176 pages)
  • P Liò and P Zuliani (Eds.) Automated Reasoning for Systems Biology and Medicine. Chapter 3. Springer, ISBN 3030172961, Jun 2019. (474 pages)
Articles
  • W Sun, V Tyurin, G Mao, I Shrivastava, B Liu, Y Zhai, S Korolev, A Abramov, P Angelova, I Miller, O Beharier, H Dar, O Kapralov, T Hastings, J Greenamyre, C Chu, I Bahar, Y Sadovsky, H Bayır, Y Tyurina, R He, V Kagan iPLA2G6 Protects Cells against Ferroptosis by Hydrolyzing the Lipid Signal of Death, 15-HpETE-PE: Relevance to Parkinson Disease Pathogenesis, Nature Neuroscience, under review (2020).PDF *
  • B Liu. A Model Checking-based Analysis Framework for Systems Biology Models, The 57th ACM/IEEE Design Automation Conference (DAC), San Francisco, US (2020). IEEE, pp.1-6PDF *
  • Q Shi, F Pei, G Silverman, S Pak, D Perlmutter, B Liu, I Bahar. Mechanisms of Action of Autophagy Modulators Dissected by Quantitative Systems Pharmacology Analysis, International Journal of Molecular Sciences, 21(8). 2855 (2020). doi: 10.3390/ijms21082855PDF *
  • S Thermozier, W Hou, X Zhang, D Shields, R Fisher, H Bayir, V Kagam, J Yu, B Liu, I Bahar, M W Epperly, P Wipf, H Wang, and J S Greenberger. Anti-Ferroptosis Drug Enhances Total Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis, Radiation Research, [Epub ahead of print] (2020). doi: 10.1667/RR15486.1PDF *
  • O Kapralov, Q Yang, H Dar, Y Tyurina, T Anthonymuthu, R Kim, C St. Croix, K Mikulska-Ruminska, B Liu, I Shrivastava, V Tyurin, H-C Ting, Y Wu, Y Gao, R Domingues, D Stoyanovsky, R Mallampalli, I Bahar, D Gabrilovich, H Bayir, and V Kagan Redox Lipid Reprogramming Commands Susceptibility of Macrophages and Microglia to Ferroptotic Death, Nature Chemical Biology, 16:2780-290 (2020). doi: 10.1038/s41589-019-0462-8PDF *
  • S Thermozier, X Zhang, W Hou, R Fisher, M W Epperly, B Liu, I Bahar, S Markovina, C Luke, G Silverman, and J S Greenberger. Radioresistance of Serpinb3a-/- Mice and Derived Hematopoietic and Marrow Stromal Cell Lines, Radiation Research, 192(3):267-281 (2019). doi: 10.1667/RR15379.1.PDF *
  • F Pei, H Li, B Liu, I Bahar. Quantitative Systems Pharmacological Analysis of Drugs of Abuse Reveals the Pleiotropy of Their Targets and the Effector Role of mTORC1, Frontiers in Pharmacology, 10:191 (2019). doi: 10.3389/fphar.2019.00191 PDF *
  • B Liu, B Gyori, P S Thiagarajan. Statistical Model Checking based Analysis of Biological Networks Automated Reasoning for Systems Biology and Medicine, 63-92 (2019). doi: 10.1007/978-3-030-17297-8_3PDF *
  • J Steinman, M Epperly, Wen Hou, J Willis, H Wang, R Fisher, B Liu, I Bahar, T McCaw, V Kagan, H Bayir, J Yu, P Wipf, S Li, M S Huq, J S Greenberger. Improved Total Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways, Radiation Research, 189(1):68-83 (2018). doi: 10.1667/RR14787.1PDF *
  • J S Greenberger, B Liu, I Bahar, H Bayir, and V Kagan. Radiation Disease: Cytokines and the Stages of Apoptosis, Necroptosis, Ferroptosis, Parthanatos, Lysosomal Necrosis, Pyroptosis, and Overlapping Networks, Radiation Biology Methods, Chapter XII (2018).PDF *
  • J S Greenberger, B Liu, V Kagan, H Bayir, and I Bahar.Radiation Biologic Pathways Intersection and Integration with Other Pathways, Radiation Biology Methods, Chapter XIII (2018).PDF *
  • B Liu, Z Oltvai, H Bayir, G Silverman, S Pak, D Perlmutter, I Bahar. Quantitative Assessment of Cell Fate Decision between Autophagy and Apoptosis, Nature Scientific Reports, 7:17605 (2017).PDF *
  • V E Kagan, G Mao, F Qu, J P F Angeli, S Doll, C S Croix, H Dar, B Liu, V A Tyurin, V B Ritov, O A Kapralov, A A Amoscato, J Jiang, T Anthonymuthu, D Mohammadyani, Q Yang, J Klein-Seetharaman, S Watkins, I Bahar, J Greenberger, R Mallampalli, B R Stockwell, Y Y Tyurina, M Conrad, H Bayir. Oxidized Arachidonic and Adrenic PEs Navigate Cells to Ferroptosis, Nature Chemical Biology, 13:81-90 (2017). doi:10.1038/nchembio.2238.PDF *
  • B Liu, J R Faeder. Parameter Estimation of Rule-based Models Using Statistical Model Checking, IEEE International Conference on Bioinformatics and Biomedicine (BIBM), Shenzhen, China (2016). IEEE, pp. 1458-1464.PDF *
  • Q Wang, N Miskov-Zivanov, B Liu, J R Faeder, M Lotze, E M Clarke. Formal Modeling and Analysis of Pancreatic Cancer Microenvironment, Computational Methods in Systems Biology (CMSB), Cambridge, UK (2016). Springer, LNCS:9859, pp. 289-305.PDF *
  • B Liu, Q Liu, S Palaniappan, L Yang, I Bahar, P S Thiagarajan, J L Ding. Innate Immune Memory and Homeostasis May Be Conferred Through crosstalk between TLR3 and TLR7 Pathways, Science Signaling, 9(436) ra70 (2016).PDF *
  • B Gyori, B Liu, S Paul, R Ramanathan, and P S Thiagarajan. Approximate Probabilistic Verification of Hybrid Systems. Hybrid Systems Biology (HSB), Madrid, Spain (2015). Springer, LNCS:9271, pp. 96-116.PDF *
  • C Kaya, B Liu, J R Faeder, I Bahar. Unified Model of Synaptic Transmission. Biophysical Journal, 108(2) 155a (2015).PDF *
  • G F Cooper, I Bahar, M J Becich, P V Benos, J Berg, J U Espino, C Glymour, R C Jacobson, M Kienholz, A V Lee, X Lu, R Scheines, Center for Causal Discovery team. The center for causal discovery of biomedical knowledge from big data Journal of the American Medical Informatics Association, 22(6):1132-1136 (2015).PDF *
  • B Liu, S Kong, S Gao, P Zuliani and E M Clarke. Towards Personalized Cancer Therapy Using Delta-Reachability Analysis. Hybrid Systems: Computation and Control (HSCC), Seattle, USA (2015). ACM, pp. 227-232.PDF *
  • B Liu, D Bhatt, Z N Oltvai, J S Greenberger, I Bahar. Significance of p53 Dynamics in Regulating Apoptosis in Response to Ionizing Radiation, and Polypharmacological Strategies. Nature Scientific Reports, 4:6245 (2014).PDF *
  • B Liu, S Kong, S Gao, P Zuliani and E M Clarke. Parameter Synthesis for Cardiac Cell Hybrid Models Using Delta-Decisions. Computational Methods in Systems Biology (CMSB), Manchester, UK (2014). Springer, LNCS:8859, pp. 99-113.PDF *
  • H Zhou, S Gao, N N Nguyen, M Fan, J Jin, B Liu, L Zhao, G Xiong, M Tan, S Li, L Wong. Stringent Homology-based Prediction of H. sapiens-M. tuberculosis H37Rv Protein-Protein Interactions. Biology Direct, 9(5):1-52 (2014). Highly Accessed.PDF *
  • A Hagiescu, B Liu, R. Ramanathan, S K Palaniappan, Z Cui, B Chattopadhyay, W F Wong, P S Thiagarajan. GPU Code Generation for ODE-Based Applications with Phased Shared-data Access Patterns. ACM Transactions on Architecture and Code Optimization, 10(4):551-5519 (2013).PDF *
  • S Palaniappan, B Gyori, B Liu, D Hsu, P S Thiagarajan and E M Clarke. Statistical Model Checking Based Calibration and Analysis of Bio-pathway Models. Computational Methods in Systems Biology (CMSB), Klosterneuburg, Austria (2013). Springer, LNCS:8130, pp 120-134.PDF *
  • B Liu, A Hagiescu, S K Palaniappan, B Chattopadhyay, Z Cui, W F Wong, P S Thiagarajan. Approximate Probabilistic Analysis of Biopathway Dynamics. Bioinformatics, 28(11):1508-1516 (2012).PDF *
  • S K Palaniappan, S Akshay, B Liu, B Genest, P S Thiagarajan. A Hybrid Factored Frontier Algorithm for Dynamic Bayesian Networks with a Biopathways Application. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 9(5):1352-1365 (2012).PDF *
  • B Liu, P S Thiagarajan. Modeling and Analysis of Biopathways Dynamics. Journal of Bioinformatics and Computational Biology, 10(4):1231001 (2012)
  • B Liu, J Zhang, P Y Tan, D Hsu, A M Blom, B Leong, S Sethi, B Ho, J L Ding, P S Thiagarajan. A Computational and Experimental Study of the Regulatory Mechanisms of the Complement System. PLoS Computational Biology, 7(1):e1001059 (2011).
  • B Liu, D Hsu, P S Thiagarajan. Probabilistic Approximations of ODEs based Bio-Pathway Dynamics. Theoretical Computer Science, 412(21):2188-2206 (2011).PDF *
  • B Liu, P S Thiagarajan, D Hsu. Probabilistic Approximations of Signaling Pathway Dynamics. Computational Methods in Systems Biology (CMSB) , Bologna, Italy (2009). Springer, LNCS:5688, pp. 251-265.
  • T Zhu, P Korshunov, B Liu, W T Ooi. Plasma: A Scripting Language for Processing Media Streams. ACM/SPIE Multimedia Computing and Networking (MMCN), San Jose, US (2007). Proceedings of SPIE:6504, pp. 65040Q.

ReferencesEdit

  1. ^ a b c d e f g Feng, Zhaoyin (7 May 2020). "Coronavirus: Professor Bing Liu's murder fuels wild theories". BBC News. Retrieved 7 May 2020.

SourcesEdit

  • Bing Liu, personal site / Research Assistant Professor, Computational & Systems Biology Department, School of Medicine, University of Pittsburgh
  • Bing Liu, Ph.D., Research Assistant Professor, Ph.D. in Computational Systems Biology, National U of Singapore