The Big Eight Conference was an NCAA Division I-A athletic conference that operated from 1907 to 1996.
Big Eight Conference may also refer to:
- Big Eight Conference (California), a junior college athletic conference that operated from 1950 to 1962
- Big 8 Conference (California), a junior college athletic conference
- Big Eight Conference (IHSAA), Indiana and Illinois, a high school athletic conference
- Big Eight Conference (Iowa), a defunct high school athletic conference
- Big 8 Conference (Missouri), a high school athletic conference
- WIAA Big Eight Conference, Wisconsin, a high school athletic conference
This disambiguation page lists articles associated with the title Big Eight Conference.
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