Bay State may refer to:
- Massachusetts, nickname "Bay State," a U.S. state with shores on Massachusetts Bay, Cape Cod Bay, Buzzards Bay and Narragansett Bay
- Bay State College, a private university in Boston, Massachusetts
- Bay State Conference, a high school athletic conference in Massachusetts
- Bay State (TV series), the Boston University-produced soap opera
- Bay State Road, a street on the Boston University campus
- Bay State (musical instrument brand), a brand of musical instrument made in the 19th century by John C. Haynes & Co.
- Baystate, a Japanese jazz record label
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