The Battle of Mytilene may refer to:
- Battle of Mytilene (406 BC), fought between Athens and Sparta
- Battle of Mytilene (427 BC), fought between Mytilene and Athens
- Battle of Mytilene (1457), naval battle between the Roman Catholic Church under Ludovico Trevisan and the Ottoman Empire
- Battle of Mytilene (1690), naval battle between a Venetian fleet under Daniele Dolphin and a combined Muslim fleet
This disambiguation page lists articles associated with the title Battle of Mytilene.
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