The Barnwell Railway was a shortline railroad that served western South Carolina in the late 19th century.
The Barnwell Railway was built in 1888 and ran from Barnwell, South Carolina, to Blackville, South Carolina, in Aiken County.
In 1891, the Carolina Midland Railway acquired the Barnwell Railway and consolidated it with the Blackville, Alston and Newberry Railroad's Perry-to-Blackville line.
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