Baltimore and Ohio Railroad Depot may refer to:
- Baltimore and Ohio Railroad Depot (Flora, Illinois), listed on the National Register of Historic Places in Clay County, Illinois
- Baltimore and Ohio Railroad Depot (Willard, Ohio), listed on the National Register of Historic Places in Huron County, Ohio
- Baltimore and Ohio Railroad Depot (Huntington, West Virginia), listed on the National Register of Historic Places in Cabell County, West Virginia
This disambiguation page lists articles associated with the title Baltimore and Ohio Railroad Depot.
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