The bZIP intron candida is an unconventional bZIP intron located in the HAC1 mRNA in a subgroup of fungi from Saccharomycetales order. So far all species with this type of structure belong to Metschnikowiaceae or Debaryomycetaceae families. However, some of the best known representatives of Debaryomycetaceae - Candida albicans and its closest relatives - contain the shorter RNA structure instead (bZIP intron ascomycota-like).[1] The consensus structure consists of two well conserved hairpins with loop regions defining the unconventional splice sites. The hairpins are separated by a long insertion with conserved motifs and a predicted secondary structure. Splicing performed by Ire1 results in excision of a very long intron that was first described in Candida parapsilosis.[2]
References
edit- ^ Hooks KB, Griffiths-Jones S (2011). "Conserved RNA structures in the non-canonical Hac1/Xbp1 intron". RNA Biol. 8 (4): 552–556. doi:10.4161/rna.8.4.15396. PMC 3225973. PMID 21593604.
- ^ Iracane, Elise; Donovan, Paul D.; Ola, Mihaela; Butler, Geraldine; Holland, Linda M. (2018). Mitchell, Aaron P. (ed.). "Identification of an Exceptionally Long Intron in the HAC1 Gene of Candida parapsilosis". mSphere. 3 (6). doi:10.1128/mSphere.00532-18. ISSN 2379-5042. PMC 6222058. PMID 30404939.