BTB/POZ domain-containing protein 2 is a protein that in humans is encoded by the BTBD2 gene.[5][6]

BTBD2
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesBTBD2, BTB domain containing 2
External IDsOMIM: 608531; MGI: 1933831; HomoloGene: 32365; GeneCards: BTBD2; OMA:BTBD2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017797

NM_145361
NM_001379084

RefSeq (protein)

NP_060267

n/a

Location (UCSC)Chr 19: 1.99 – 2.03 MbChr 10: 80.48 – 80.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.[6]

Interactions

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BTBD2 has been shown to interact with TOP1.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133243Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003344Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Carim-Todd L, Sumoy L, Andreu N, Estivill X, Escarceller M (Jan 2001). "Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24". Gene. 262 (1–2): 275–81. doi:10.1016/S0378-1119(00)00513-8. PMID 11179693.
  6. ^ a b "Entrez Gene: BTBD2 BTB (POZ) domain containing 2".
  7. ^ Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y, D'Arpa P (2002). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics. 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.
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Further reading

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