In molecular biology, the BSD domain is an approximately 60-amino-acid-long protein domain named after the BTF2-like transcription factors, synapse-associated proteins and DOS2-like proteins in which it is found. It is also found in several hypothetical proteins. It occurs in one or two copies in a variety of species ranging from primal protozoan to human, and can be found associated with other domains such as the BTB domain or the U-box in multidomain proteins. Its function is as yet unknown.[1]

BSD
solution structure of the bsd domain of human tfiih basal transcription factor complex p62 subunit
Identifiers
SymbolBSD
PfamPF03909
InterProIPR005607
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Secondary structure prediction indicates the presence of three predicted alpha helices, which probably form a three-helical bundle in small |domains. The third predicted helix contains neighbouring phenylalanine and tryptophan residues—less common amino acids that are invariant in all the BSD domains identified and that are the domain's most striking sequence features.[1]

Some proteins known to contain one or two BSD domains are:

References

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  1. ^ a b Doerks T, Huber S, Buchner E, Bork P (April 2002). "BSD: a novel domain in transcription factors and synapse-associated proteins". Trends in Biochemical Sciences. 27 (4): 168–70. doi:10.1016/s0968-0004(01)02042-4. PMID 11943536.

Further reading

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