Bombesin-like receptor 3

The bombesin receptor subtype 3 also known as BRS-3 or BB₃ is a protein which in humans is encoded by the BRS3 gene.

BRS3
Identifiers
Aliases	BRS3, BB3, bombesin like receptor 3, BB3R, bombesin receptor subtype 3, BBR3
External IDs	OMIM: 300107; MGI: 1100501; HomoloGene: 1307; GeneCards: BRS3; OMA:BRS3 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq26.3 Start 136,487,947 bp End 136,493,780 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X A6 Start 56,088,434 bp End 56,094,118 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell corpus epididymis testicle caput epididymis pancreatic ductal cell islet of Langerhans tail of epididymis tibialis anterior muscle right ovary left uterine tube Top expressed in gastrula embryo tibiofemoral joint lumbar spinal ganglion carotid body nucleus of stria terminalis central gray substance of midbrain hypothalamus neck sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function bombesin receptor activity G protein-coupled peptide receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane neuron projection soma plasma membrane membrane integral component of plasma membrane Biological process regulation of blood pressure G protein-coupled receptor signaling pathway bombesin receptor signaling pathway adult feeding behavior signal transduction glucose metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 680 12209 Ensembl ENSG00000102239 ENSMUSG00000031130 UniProt P32247 O54798 RefSeq (mRNA) NM_001727 NM_009766 RefSeq (protein) NP_001718 NP_033896 Location (UCSC) Chr X: 136.49 – 136.49 Mb Chr X: 56.09 – 56.09 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Mammalian bombesin-like peptides are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin-like receptor-3 (BRS3; this article).

BB₃ is a G protein-coupled receptor. BB₃ only interacts with known naturally occurring bombesin-related peptides with low affinity and therefore, as it has no natural high-affinity ligand, is classified as an orphan receptor.

Further reading

• Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F (1994). "Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus" (PDF). FEBS Lett. 340 (3): 260–4. doi:10.1016/0014-5793(94)80150-9. PMID 8131855. S2CID 99786.
• Fathi Z, Corjay MH, Shapira H, et al. (1993). "BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells". J. Biol. Chem. 268 (8): 5979–84. doi:10.1016/S0021-9258(18)53415-3. PMID 8383682.
• Kane MA, Toi-Scott M, Johnson GL, et al. (1996). "Bombesin-like peptide receptors in human bronchial epithelial cells". Peptides. 17 (1): 111–8. doi:10.1016/0196-9781(95)02088-8. PMID 8822519. S2CID 30893871.
• Ohki-Hamazaki H, Watase K, Yamamoto K, et al. (1997). "Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity". Nature. 390 (6656): 165–9. Bibcode:1997Natur.390..165O. doi:10.1038/36568. PMID 9367152. S2CID 4400418.
• Ryan RR, Weber HC, Hou W, et al. (1998). "Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3". J. Biol. Chem. 273 (22): 13613–24. doi:10.1074/jbc.273.22.13613. PMID 9593699.
• Liu J, Lao ZJ, Zhang J, et al. (2002). "Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3)". Biochemistry. 41 (28): 8954–60. doi:10.1021/bi0202777. PMID 12102638.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Hou X, Wei L, Harada A, Tatamoto K (2007). "Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells". Lung Cancer. 54 (2): 143–8. doi:10.1016/j.lungcan.2006.08.005. PMID 16979789.
• Tan YR, Qin XQ, Xiang Y, et al. (2007). "PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells". Biochem. J. 405 (1): 131–7. doi:10.1042/BJ20061754. PMC 1925247. PMID 17355223.

External links

• "Bombesin Receptors: BB₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
• bombesin+receptor+subtype+3 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human BRS3 genome location and BRS3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.