Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.[5][6]

BRMS1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBRMS1, breast cancer metastasis suppressor 1, transcriptional repressor and anoikis regulator, BRMS1 transcriptional repressor and anoikis regulator
External IDsOMIM: 606259; MGI: 2388804; HomoloGene: 32260; GeneCards: BRMS1; OMA:BRMS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015399
NM_001024957
NM_001024958

NM_134155
NM_001374047
NM_001374048

RefSeq (protein)

NP_001020128
NP_056214

NP_598916
NP_001360976
NP_001360977

Location (UCSC)Chr 11: 66.34 – 66.35 MbChr 19: 5.09 – 5.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines.[7] The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000174744Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000080268Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seraj MJ, Samant RS, Verderame MF, Welch DR (Jun 2000). "Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13". Cancer Research. 60 (11): 2764–9. PMID 10850410.
  6. ^ a b "Entrez Gene: BRMS1 breast cancer metastasis suppressor 1".
  7. ^ Penn State Researchers Find Breast Cancer Metastasis Suppressor Gene
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Further reading

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