B80 may refer to:
- B-80, a Zulu-class submarine bought from the Soviets in 1991
- B80, a model of the Beechcraft Queen Air twin-engined light aircraft
- B80, a model of the Rolls-Royce B range engines
- B80, Studley, Warwickshire's postcode district in the B postcode area
- Sicilian Defence, Scheveningen Variation (ECO code: B80), an chess opening that is a line of the Open Sicilian
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