V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.[5][6][7]

VTCN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesVTCN1, B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1, V-set domain containing T cell activation inhibitor 1, V-set domain containing T-cell activation inhibitor 1
External IDsOMIM: 608162; MGI: 3039619; HomoloGene: 11627; GeneCards: VTCN1; OMA:VTCN1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253849
NM_001253850
NM_024626

NM_178594

RefSeq (protein)

NP_001240778
NP_001240779
NP_078902

NP_848709

Location (UCSC)Chr 1: 117.14 – 117.21 MbChr 3: 100.73 – 100.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM][7]

B7-H4 is an immune checkpoint molecule.

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134258Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051076Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L (June 2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity". Immunity. 18 (6): 849–61. doi:10.1016/S1074-7613(03)00152-3. PMID 12818165.
  6. ^ Prasad DV, Richards S, Mai XM, Dong C (June 2003). "B7S1, a novel B7 family member that negatively regulates T cell activation". Immunity. 18 (6): 863–73. doi:10.1016/S1074-7613(03)00147-X. PMID 12818166.
  7. ^ a b "Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1".

Further reading

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