B46 may refer to:
- Bundesstraße 46, a German road
- B46 (New York City bus), a bus line in Brooklyn
- B46 nuclear bomb
- HLA-B46, a HLA-B serotype
- B46, the Taimanov variation of the Sicilian Defence chess opening
- Convair XB-46, an American aircraft
This disambiguation page lists articles associated with the same title formed as a letter–number combination.
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