Aphthonius may refer to:
- Aelius Festus Aphthonius (4th century), Latin grammarian, possibly of African origin
- Aphthonius of Antioch (late 4th century), Greek sophist and rhetorician
- Aphthonius of Alexandria (4th century), ancient Gnostic bishop
This disambiguation page lists articles associated with the title Aphthonius.
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