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Cholinesterase inhibitor

  (Redirected from Anticholinesterase)

Cholinesterase inhibitors, also known as anti-cholinesterase, are chemicals that prevent the breakdown of the neurotransmitter acetylcholine and/or butyrylcholine. This group of inhibitors are divided into two subgroups, i.e. acetyl-cholinesterase inhibitors and butyrul-cholinesterase inhibitors (BuChE).[1][2] They may be used as drugs for a number of disorders, including Alzheimer's and myasthenia gravis, and also as chemical weapons and insecticides[citation needed]. Side effects when used as drugs may include loss of appetite, nausea, vomiting, loose stools, vivid dreams at night, dehydration, rash, bradycardia, peptic ulcer disease, seizures, weight loss, rhinorrhea, salivation, muscle cramps, fasciculations.[3]

The efficacy of cholinesterase inhibitor generally seen in the third month since administration.[3]

Contents

Binding affinityEdit

Acetylcholinesterase inhibitorsEdit

Phenserine, huperzine A, and BW284c51 are selective AChE inhibitors. [4]

Butyrylcholinesterase inhibitorEdit

Tetra (monoisopropyl) pyrophosphoramide (Iso-OMPA) and ethopropazine are selective BChE inhibitors.[4]

AChE & BChE inhibitorEdit

Paraoxon and rivastigmine are both acetylcholinesterase inhibitor and butyrylcholinesterase inhibitor.[4]

Cholinesterase inhibitor toxicityEdit

See alsoEdit

ReferenceEdit

  1. ^ English, Brett A.; Webster, Andrew A. (2012). "Acetylcholinesterase and its Inhibitors". Primer on the Autonomic Nervous System. Elsevier. pp. 631–633. doi:10.1016/b978-0-12-386525-0.00132-3. ISBN 978-0-12-386525-0.
  2. ^ Deutch, Ariel Y.; Roth, Robert H. (2014). "Pharmacology and Biochemistry of Synaptic Transmission". From Molecules to Networks. Elsevier. pp. 207–237. doi:10.1016/b978-0-12-397179-1.00007-5. ISBN 978-0-12-397179-1.
  3. ^ a b Budson, Andrew E.; Solomon, Paul R. (2016). "Cholinesterase Inhibitors". Memory Loss, Alzheimer's Disease, and Dementia. Elsevier. pp. 160–173. doi:10.1016/b978-0-323-28661-9.00016-0. ISBN 978-0-323-28661-9.
  4. ^ a b c Waiskopf, Nir; Soreq, Hermona (2015). "Cholinesterase Inhibitors". Handbook of Toxicology of Chemical Warfare Agents. Elsevier. pp. 761–778. doi:10.1016/b978-0-12-800159-2.00052-x. ISBN 978-0-12-800159-2.