Andy or Andrew O'Brien may refer to:
- Andy O'Brien (footballer) (born 1979), Irish footballer
- Andy O'Brien (hurler) (born 1988), Irish hurler
- Andy O'Brien (journalist) (1910–1987), Canadian sports journalist
- Andy O'Brien (politician) (1915–2006), Irish Fine Gael senator
- Andrew O'Brien (politician) (fl. 1990s-2010s), US Department of State official
- Andrew O'Brien (rugby) (1897–1969), New Zealand rugby footballer
Fictional edit
- Andy O'Brien (EastEnders), a character in EastEnders
This disambiguation page lists articles about people with the same name.
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