Androstenetriol (AET, androst-5-ene-3β,7β,17β-triol, β-androstenetriol, or βAET) is a steroid produced in the adrenal glands as a metabolite of DHEA.[1] It is believed to have similar effects as DHEA and androstenediol.[2] A study in rodents found that the compound was a weak androgen and estrogen, but did not attach to the androgen, estrogen, progesterone, or glucocorticoid receptors.[1] Synthetic analogs of AET known as HE3286[3] and NE3107 have been developed.[4]
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| Formula | C19H30O3 |
| Molar mass | 306.446 g·mol−1 |
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References edit
- ^ a b Ahlem, Clarence N.; Auci, Dominick L.; Nicoletti, Ferdinando; Pieters, Raymond; Kennedy, Michael R.; Page, Theodore M.; Reading, Christopher L.; Enioutina, Elena Y.; Frincke, James M. (2011). "Pharmacology and immune modulating properties of 5-androstene-3β,7β,17β-triol, a DHEA metabolite in the human metabolome". The Journal of Steroid Biochemistry and Molecular Biology. 126 (3): 87–94. doi:10.1016/j.jsbmb.2011.04.010. ISSN 0960-0760. PMID 21570467. S2CID 5123272.
- ^ Dillon, Joseph S. (2005). "Dehydroepiandrosterone, Dehydroepiandrosterone Sulfate and Related Steroids: Their Role in Inflammatory, Allergic and Immunological Disorders". Current Drug Targets - Inflammation & Allergy. 4 (3): 377–385. doi:10.2174/1568010054022079. PMID 16101547.
- ^ Reading, Christopher L.; Frincke, James M.; White, Steven K. (24 February 2012). "Molecular Targets for 17α-Ethynyl-5-Androstene-3β,7β,17β-Triol, an Anti-Inflammatory Agent Derived from the Human Metabolome". PLOS ONE. 7 (2): e32147. Bibcode:2012PLoSO...732147R. doi:10.1371/journal.pone.0032147. ISSN 1932-6203. PMC 3286445. PMID 22384159.
- ^ Reading, Chris L; Ahlem, Clarence N; Parameswaran, Narayanan (December 2021). "Rationale for an anti-inflammatory insulin sensitizer in a phase 3 Alzheimer's disease trial". Alzheimer's & Dementia. 17 (S9). doi:10.1002/alz.057438.