In 1448, Pope Nicholas V appointed Andrew II as Archbishop of Antivari in Rome.
Under Andrew's permission, the Church of Saint Nicholas near the fortification of the city of Antivari was given to Conventual Franciscans, and there they built a monastery.
In the course of the year 1450, Andrew II served as Skanderbeg's ambassador to the Pope. Two years later, Andrew participated in the reconciliation between the Albanian Dukagjini and Kastrioti clans in Dyrrhachium.
In 1459, Andrew resigned as Archbishop and relocated himself to Rome, where he died in 1462.