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Andreas Hierlemann

Andreas Hierlemann (17 August 1964) is a German chemist and professor of Biosystems Engineering at ETH Zurich. He is known for his work in the field of CMOS-based chemical and biomicrosensors and high-density microelectrode arrays.

Andreas Hierlemann
17 August 1964 (1964-08-17) (age 54)
Known forDevelopment of CMOS chemical and biomicrosensors, CMOS high-density microelectrode arrays
Scientific career
FieldsBiosystems engineering
InstitutionsETH Zurich



From 1985-91 Hierlemann studied chemistry at the University of Tübingen, Germany. He received a PhD from the University of Tübingen in 1996 for his work on Mass-sensitive detection of organic volatiles using modified polysiloxanes. 1997-98 he held postdoctoral positions at Texas A&M University in College Station, Texas, USA, and at Sandia National Laboratories in Albuquerque, New Mexico, USA. From 1999 to 2004 he was research team leader at the Physical Electronics Laboratory in the Department of Physics of ETH Zürich, Switzerland, becoming associate professor for microsensors in 2004. 2008 he was named full professor of Biosystems Engineering, Department of Biosystems Science and Engineering of ETH Zurich in Basel, Switzerland.

Scientific contributionEdit

Hierlemann’s research initially was mostly in the area of chemical sensors and microsensors.[1][2] In particular, he worked on the detection of organic volatiles and the discrimination of enantiomers in the gas phase.[3][4] He then adopted microtechnology and, specifically, CMOS-based microelectronics to devise complex microsensor systems.[1][5][6] The current interdisciplinary research is rooted in engineering and physics and targeted at questions in biology and medicine. It includes the development of CMOS-based integrated chemical and biomicrosystems,[1][5][6] as well as bioelectronics and high-density microelectrode arrays.[7][8][9] The high-density microelectrode arrays are used for fundamental research in information processing and signaling characteristics of neurons or brain cells.[7][8][9] Moreover, the research group is engaged in the development of microfluidics for investigating the characteristics of single cells and microtissues.

Applications of Hierlemann's and his group's technologies are in the fields of systems biology, drug testing, personalized medicine, and neuroscience.


Publication listEdit


  1. ^ a b c C. Hagleitner, A. Hierlemann, D. Lange, A. Kummer, N. Kerness, O. Brand, H. Baltes “ Smart Single-Chip Gas Sensor Microsystem”, Nature, 414, (2001) pp. 293-296.
  2. ^ A. Hierlemann, R. Gutierrez-Osuna (2008). Higher-order Chemical Sensing. Chemical Reviews, 108, pp. 563-613.
  3. ^ K. Bodenhöfer, A. Hierlemann, J. Seemann, G. Gauglitz, B. Koppenhoefer, W. Göpel, "Chiral Discrimination using Piezoelectric and Optical Gas Sensors", Nature, 387 (1997) 577-580.
  4. ^ P. Kurzawski, A. Bogdanski, V. Schurig, R. Wimmer, A. Hierlemann (2008). Opposite signs of capacitive microsensor signals upon exposure to the enantiomers of methyl propionates. Angewandte Chemie International Edition, 47, pp. 913-916.
  5. ^ a b A. Hierlemann (2005). Integrated Chemical Microsensor Systems in CMOS Technology, Springer Verlag,p. 229, ISBN 3-540-23782-8.
  6. ^ a b S. Hafizovic, D. Barrettino, T. Volden, J. Sedivy, K.-U. Kirstein, O. Brand, A. Hierlemann (2004). Single-chip mechatronic microsystem for surface imaging and force response studies. PNAS, Vol. 101, No. 49, pp. 17011-17015.
  7. ^ a b U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann (2009). Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices. Biosensors and Bioelectronics, 24, pp. 2191-2198.
  8. ^ a b A. Hierlemann, U. Frey, S. Hafizovic, F. Heer (2011). Growing Cells atop Microelectronic Chips: Interfacing Electrogenic Cells in Vitro with CMOS-based Microelectrode Arrays. Proceedings of the IEEE, Vol. 99, No. 2, pp. 252-284.
  9. ^ a b D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Müller, M. Fiscella, H. Takahashi, A. Hierlemann (2013). Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites. Nature Communications 2013, 4:2181.

External linksEdit