Human variability(Redirected from Anatomical variation)
Human variability, or human variation, is the range of possible values for any characteristic - physical or mental - of human beings.
Variation is inherent in all species, and is necessary to ensure diversity within the species, and thus the species’ survival over time. There are conflicting views on the attitudes towards variability traits according to each society that is rooted in cultural taste or local traditions. The variations that are often evaluated differently are mental abilities, body shape, and skin color. These variations may come from genetics, in the form of heritable traits obtained from parents, or from the environment, a factor of both prenatal health and subsequent lifestyle choices. Humans are said to have a higher degree of variation than most other species, and an increased awareness of variation, which has a significant societal impact in the way humans interact with and evaluate others.
Sources of human variabilityEdit
Human variability is attributed to a combination of environmental and genetic sources including:
- Environmental Sources
- Prenatal environment
- Nutrition and Malnutrition
- Quality of life and Health care
- Pollution and Toxin exposure and other stressors
- Family environment and upbringing (especially before age 5)
- Genetic Sources
Many genetic differences (polymorphisms) have little effect on health or reproductive success but help to distinguish one population from another. It is helpful for researchers in the field of population genetics to study ancient migrations and relationships between population groups.
Climate and diseaseEdit
Other important factors of environmental factors include climate and disease. Climate has effects on determining what kinds of human variation is more adaptable to survive without much restrictions and hardships. For example, people, who live in the climate where there is a lot of exposure to sunlight, has a darker color of skin tone. With evolution favors protection of folate (folic acid) from UV radiation, they have darker skin tone with more melanin to make sure child development is smooth and success. On the other hand, people who lived farther away from the equator have a lighter skin tone. They have lighter skin tone because they need more exposure and absorbance of sunlight to make sure the body produce enough vitamin D for survival.
Blackfoot disease is a disease caused by environmental pollution and causes people to have black, charcoal-like skin in the lower limbs. This is caused by arsenic pollution in water and food source. This is an example of how disease can affect human variation. Another disease that can affect human variation is syphilis, a sexual transmitted disease. Syphilis does not affect human variation until the middle stage of the disease. It then starts to grow rashes all over the body, affecting people's human variation.
Phenotypic variation is a combination of one's genetics and their surrounding environment, with no interaction or mutual influence between the two. This means that a significant portion of human variability can be controlled by human behavior. Nutrition and diet play a substantial role in determining phenotype because they are arguably the most controllable forms of environmental factors that create epigenetic changes. This is because they can be changed or altered relatively easily as opposed to other environmental factors like location. If people are reluctant to changing their diets, consuming harmful foods can have chronic negative effects on variability. One such instance of this occurs when eating certain chemicals through one's diet or consuming carcinogens, which can have adverse effects on individual phenotype. For example, Bisphenol A (BPA) is a known endocrine disruptor that mimics the hormone estradiol and can be found in various plastic products. BPA seeps into food or drinks when the plastic containing it is heated up and begins to melt. When these contaminated substances are consumed, especially often and over long periods of time, one's risk of diabetes and cardiovascular disease increases. BPA also has the potential to alter "physiological weight control patterns." Examples such as this demonstrate that preserving a healthy phenotype largely rests on nutritional decision-making skills.
The concept that nutrition and diet affect phenotype extends to what the mother eats during pregnancy, which can have drastic effects on the outcome of the phenotype of the child. A recent study by researchers at the MRC International Nutrition Group shows that "methylation machinery can be disrupted by nutrient deficiencies and that this can lead to disease" susceptibility in newborn babies. The reason for this is because methyl groups have the ability to silence certain genes. Increased deficiencies of various nutrients such as this have the potential to permanently change the epigenetics of the baby.
Genetic variation in humans, as for the purposes of this section, will refer to any variance in phenotype which results from heritable allele expression, mutations, and epigenetic changes. While human phenotypes may seem diverse, individuals actually differ by only 1 in every 1,000 genes and is primarily the result of inherited genetic differences. Pure consideration of alleles is often referred to as Mendelian Genetics, or more properly Classical Genetics, and involves the assessment of whether a given trait is dominant or recessive and thus, at what rates it will be inherited. The color of one's eyes was long believed to occur with a pattern of brown-eye dominance, with blue eyes being a recessive characteristic resulting from a past mutation. However, it is now understood that eye color is controlled by various genes, and thus, may not follow as distinct a pattern as previously believed. The trait is still the result of variance in genetic sequence between individuals as a result of inheritance from their parents. Common traits which may be linked to genetic patterns are earlobe attachment, hair color, and hair growth patterns.
Evolutionarily speaking, genetic mutations are the origins of differences in alleles between individuals. However, mutations may also occur within a person's life-time and be passed down from parent to offspring. In some cases, mutations may result in genetic diseases, such as Cystic Fibrosis, which is the result of a mutation to the CFTR gene that is recessively inherited from both parents. In other cases, mutations may be harmless or phenotypically unnoticeable. We are able to treat biological traits as manifestations of either a single loci or multiple loci, labeling said biological traits as either monogenic or polygenic, respectively. Concerning polygenic traits it may be essential to be mindful of inter-genetic interactions or epistasis. Although epistasis is a significant genetic source of biological variation, it is only additive interactions that are heritable as other epistatic interactions involve recondite inter-genetic relationships. Epistatic interactions in of themselves vary further with their dependency on the results of the mechanisms of recombination and crossing over.
The ability of genes to be expressed may also be a source of variation between individuals and result in changes to phenotype. This may the result of epigenetics, which are founded upon an organism's phenotypic plasticity, with such a plasticity even being heritable. Epigenetics may result from methylation of gene sequences leading to the blocking of expression or changes to histone protein structuring as a result of environmental or biological cues. Such alterations influence how genetic material is handled by the cell and to what extent certain DNA sections are expressed and compose the epigenome. The division between what can be considered as a genetic source of biological variation and not becomes immensely arbitrary as we approach aspects of biological variation such as epigenetics. Indeed, gene specific gene expression and inheritance may be reliant on environmental influences.
Measurement of human variation can fall under the purview of several scholarly disciplines, many of which lie at the intersection of biology and statistics. The methods of biostatistics, the application of statistical methods to the analysis of biological data, and bioinformatics, the application of information technologies to the analysis of biological data, are utilized by researchers in these fields to uncover significant patterns of variability. Some fields of scientific research include the following:
Demography is a branch of statistics and sociology concerned with the statistical study of populations, especially humans. A demographic analysis can measure various metrics of a population, most commonly metrics of size and growth, diversity in culture, ethnicity, language, religious belief, political belief, etc. Biodemography is a subfield which specifically integrates biological understanding into demographics analysis.
In the social sciences, social research is conducted and collected data is analyzed under statistical methods. The methodologies of this research can be divided into qualitative and quantitative designs. Some example subdisciplines include:
- Anthropology, the study of human societies. Comparative research in subfields of anthropology may yield results on human variation with respect to the subfield's topic of interest.
- Psychology, the study of behavior from a mental perspective. Does a lot of experiments and analysis grouped into quantitative or qualitative research methods.
- Sociology, the study of behavior from a social perspective. Sociological research can be conducted in either quantitative or qualitative formats, depending on the nature of data collected and the subfield of sociology under which the research falls. Analysis of this data is subject to quantitative or qualitative methods. Computational sociology is also a method of producing useful data for studies of social behavior.
Anthropometry is the study of the measurements of different parts of the human body. Common measurements include height, weight, organ size (brain, stomach, penis, vagina), and other bodily metrics such as waist-hip ratio. Each measurement can vary significantly between populations; for instance, the average height of males of European descent is 178 cm ± 7 cm and of females of European descent is 165 cm ± 7 cm. Meanwhile, average height of Nilotic males in Dinka is 181.3 cm.
Applications of anthropometry include ergonomics, biometrics, and forensics. Knowing the distribution of body measurements enable designers to build better tools for workers. Anthropometry is also used when designing safety equipment such as seat belts. In biometrics, measurements of fingerprints and iris patterns can be used for secure identification purposes.
Measuring genetic variationEdit
Human genomics and population genetics are the study of the human genome and variome, respectively. Studies in these areas may concern the patterns and trends in human DNA. The Human Genome Project and The Human Variome Project are examples of large scale studies of the entire human population to collect data which can be analyzed to understand genomic and genetic variation in individuals, respectively.
- The Human Genome Project is the largest scientific project in the history of biology. At a cost of $3.8 billion in funding and over a period of 13 years from 1990 to 2003, the project processed through DNA sequencing the approximately 3 billion base pairs and catalogued the 20,000 to 25,000 genes in human DNA. The project made the data available to all scientific researchers and developed analytical tools for processing this information. A particular finding regarding human variability due to difference in DNA made possible by the Human Genome Project is that any two individuals share 99.9% of their nucleotide sequences.
- The Human Variome Project is a similar undertaking with the goal of identification and categorization of the set of human genetic variation, specifically variations which are medically pertinent. This project will also provide a data repository for further research and analysis of disease. The Human Variome Project was launched in 2006 and is being run by an international community of researchers and representatives, including collaborators from the World Health Organization and the United Nations Educational, Scientific, and Cultural Organization.
Genetic drift is one method by which variability occurs in populations. Unlike natural selection, genetic drift occurs when alleles decrease randomly over time and not as a result of selection bias. Over a long history, this can cause significant shifts in the underlying genetic distribution of a population. We can model genetic drift with the Wright-Fisher model. In a population of N with 2N genes, there are two alleles with frequencies p and q. If the previous generation had an allele with frequency p, then the probability that the next generation has k of that allele is:
Over time, one allele will be fixed when the frequency of that allele reaches 1 and the frequency of the other allele reaches 0. The probability that any allele is fixed is proportional to the frequency of that allele. For two alleles with frequencies p and q, the probability that p will be fixed is p. The expected number of generations for an allele with frequency p to be fixed is:
Where Ne is the effective population size.
Single-nucleotide polymorphism or SNPs are variations of a single nucleotide. SNPs can occur in coding or non-coding regions of genes and on average occur once every 300 nucleotides. SNPs in coding regions can cause synonymous, missense, and nonsense mutations. SNPs have shown to be correlated with drug responses and risk of diseases such as sickle-cell anemia, Alzheimer's disease, cystic fibrosis, and more.
DNA profiling, whereby a DNA fingerprint is constructed by extracting a DNA sample from body tissue or fluid. Then, it is segmented using restriction enzymes and each segment marked with probes then exposed on X-ray film. The segments form patterns of black bars;the DNA fingerprint. DNA Fingerprints are used in conjunction with other methods in order to individuals information in Federal programs such as CODIS (Combined DNA Index System for Missing Persons) in order to help identify individuals 
Mitochondrial DNA, which is only passed from mother to child. The first human population studies based on mitochondrial DNA were performed by restriction enzyme analyses (RFLPs) and revealed differences between the four ethnic groups (Caucasian, Amerindian, African, and Asian). Differences in mtDNA patterns have also been shown in communities with a different geographic origin within the same ethnic group
Alloenzymic variation, a source of variation that identifies protein variants of the same gene due to amino acid substitutions in proteins. After grinding tissue to release the cytoplasm, wicks are used to absorb the resulting extract and placed in a slit cut into a starch gel. A low current is run across the gel resulting in a positive and negative ends. Proteins are then separated by charge and size, with the smaller and more highly charged molecules moving more quickly across the gel. This techniques does underestimate true genetic variability as there may be an amino acid substitution but if the amino acid is not charged differently than the original no difference in migration will appear it is estimated that approximately 1/3 of the true genetic variation is not expressed by this technique.
Structural variation, which can include insertions, deletions, duplications, and mutations in DNA. Within the human population, about 13% of the human genome is defined as structurally variant.
Phenotypic variation, which accounts for both genetic and epigenetic factors that affect what characteristics are shown. For applications such as organ donations and matching, phenotypic variation of blood type, tissue type, and organ size are considered.
Measurement of human variation may also be initiated by governmental parties. A government may conduct a census, the systematic recording of an entire population of a region. The data may be used for calculating metrics of demography such as sex, gender, age, education, employment, etc.; this information is utilized for civic, political, economic, industrial, and environmental assessment and planning.
Commercial motivation for understanding variation in human populations arises from the competitive advantage of tailoring products and services for a specific target market. A business may undertake some form of market research in order to collect data on customer preference and behavior and implement changes which align with the results.
Social significance and valuationEdit
Both individuals and entire societies and cultures place values on different aspects of human variability; however, values can change as societies and cultures change. Not all people agree on the values or relative rankings, and neither do all societies and cultures. Nonetheless, nearly all human differences have a social value dimension. Examples of variations which may be given different values in different societies include skin color and/or body structure. Race and sex have a strong value difference, while handedness has a much weaker value difference.The values given to different traits among human variability are often influenced by what phenotypes are more prevalent locally. Local valuation may affect social standing, reproductive opportunities, or even survival.
Differences may vary or be distributed in various ways. Some, like height for a given sex, vary in close to a "normal" or Gaussian distribution. Other characteristics (e.g., skin color) vary continuously in a population, but the continuum may be socially divided into a small number of distinct categories. Then, there are some characteristics that vary bimodally (for example, handedness), with fewer people in intermediate categories.
Classification and evaluation of traitsEdit
When an inherited difference of body structure or function is severe enough to cause a significant hindrance in certain perceived abilities, it is termed a genetic disease, but even this categorization has fuzzy edges. There are many instances in which the degree of negative value of a human difference depends completely on the social or physical environment. For example, in a society with a large proportion of deaf people (as Martha's Vineyard in the 19th century), it was possible to deny that deafness is a disability. Another example of social renegotiation of the value assigned to a difference is reflected in the controversy over management of ambiguous genitalia, especially whether abnormal genital structure has enough negative consequences to warrant surgical correction.
Furthermore, many genetic traits may be advantageous in certain circumstances and disadvantageous in others. Being a heterozygote or carrier of the sickle-cell disease gene confers some protection against malaria, apparently enough to maintain the gene in populations of malarial areas. In a homozygous dose it is a significant disability.
Each trait has its own advantages and disadvantages, but sometimes a trait that is found desirable may not be favorable in terms of certain biological factors such as reproductive fitness, and traits that are not highly valued by the majority of people may be favorable in terms of biological factors. For example, women tend to have fewer pregnancies on average than before and therefore net worldwide fertility rates are dropping. Moreover, this leads to the fact that multiple births tend to be favorable in terms of number of children and therefore offspring count; when the average number of pregnancies and the average number of children was higher, multiple births made only a slight relative difference in number of children. However, with fewer pregnancies, multiple births can make the difference in number of children relatively large. A hypothetical scenario would be that couple 1 has ten children and couple 2 has eight children, but in both couples, the woman undergoes eight pregnancies. This is not a large difference in ratio of fertility. However, another hypothetical scenario can be that couple 1 has three children and couple 2 has one child but in both couples the woman undergoes one pregnancy (in this case couple 2 has triplets). When the proportion of offspring count in the latter hypothetical scenario is compared, the difference in proportion of offspring count becomes higher. A trait in women known to greatly increase the chance of multiple births is being a tall woman (presumably the chance is further increased when the woman is very tall among both women and men). Yet very tall women are not viewed as a desirable phenotype by the majority of people, and the phenotype of very tall women has not been highly favored in the past. Nevertheless, values placed on traits can change over time.
Such an example is homosexuality. In Ancient Greece, what in present terms would be called homosexuality, primarily between a man and a young boy, was not uncommon and was not outlawed. However, homosexuality became more condemned. Attitudes towards homosexuality alleviated in modern times.
Acknowledgement and study of human differences does have a wide range of uses, such as tailoring the size and shape of manufactured items. See Ergonomics.
Controversies of sociocultural and personal implicationsEdit
Possession of above average amounts of some abilities is valued by most societies. Some of the traits that societies try to measure by perception are intellectual aptitude in the form of ability to learn, artistic prowess, strength, endurance, agility, and resilience.
Each individual's distinctive differences, even the negatively valued or stigmatized ones, are usually considered an essential part of self-identity. Membership or status in a social group may depend on having specific values for certain attributes. It is not unusual for people to deliberately try to amplify or exaggerate differences, or to conceal or minimize them, for a variety of reasons. Examples of practices designed to minimize differences include tanning, hair straightening, skin bleaching, plastic surgery, orthodontia, and growth hormone treatment for extreme shortness. Conversely, male-female differences are enhanced and exaggerated in most societies.
In some societies, such as the United States, circumcision is practiced on a majority of males, as well as sex reassignment on intersex infants, with substantial emphasis on cultural and religious norms. Circumcision is highly controversial because although it offers health benefits, such as less chance of urinary tract infections, STDs, and penile cancer, it is considered a drastic procedure that is not medically mandatory and argued as a decision that should be taken when the child is old enough to decide for himself. Similarly, sex reassignment surgery goes against traditional Christian values and is argued as unethical when performed on children but offers psychiatric health benefits to individuals who believe they need to transition.
Much controversy surrounds the assigning or distinguishing of some variations, especially since differences between groups in a society or between societies is often debated as part of either a person's "essential" nature or a socially constructed attribution. For example, there has long been a debate among sex researchers on whether sexual orientation is due to evolution and biology (the "essentialist" position), or a result of mutually reinforcing social perceptions and behavioral choices (the "constructivist" perspective). The essentialist position emphasizes inclusive fitness as the reason homosexuality has not been eradicated by natural selection. Gay or lesbian individuals have not been greatly affected by evolutionary selection because they may help the fitness of their siblings and siblings' children, thus increasing their own fitness through inclusive fitness and maintaining evolution of homosexuality. Biological theories for same gender sexual orientation include genetic influences, neuroanatomical factors, and hormone differences but research so far has not provided any conclusive results. In contrast, the social constructivist position argues that sexuality is a result of culture and has originated from language or dialogue about sex. Mating choices are the product of cultural values, such as youth and attractiveness, and homosexuality varies greatly between cultures and societies. In this view, complexities, such as sexual orientation changing during the course of one's lifespan, are accounted for.
Controversy also surrounds the boundaries of "wellness", "wholeness," or "normality." In some cultures, differences in physical appearance, mental ability, and even sex can exclude one from traditions, ceremonies, or other important events, such as religious service. For example, in India, menstruation is not only a taboo subject but also traditionally considered shameful. Depending on beliefs, a woman who is menstruating is not allowed to cook or enter spiritual areas because she is "impure" and "cursed". There has been large-scale renegotiation of the social significance of variations which reduce the ability of a person to do one or more functions in western culture. Laws have been passed to alleviate the reduction of social opportunity available to those with disabilities. The concept of "differently abled" has been pushed by those persuading society to see limited incapacities as a human difference of less negative value.
Ideologies of superiority and inferiorityEdit
The extreme exercise of social valuation of human difference is in the definition of "human." Differences between humans can lead to an individual's "nonhuman" status, in the sense of withholding identification, charity, and social participation. Views of these variations can change enormously between cultures over time. For example, nineteenth-century European and American ideas of race and eugenics culminated in the attempts of the Nazi-led German society of the 1930s to deny not just reproduction, but life itself to a variety of people with "differences" attributed in part to biological characteristics. Hitler and Nazi leaders wanted to create a "master race" consisting of only Aryans, or blue-eyed, blonde-haired, and tall individuals, thus discriminating and attempting to exterminate those who did fit into this ideal.
Contemporary controversy continues over "what kind of human" is a fetus or child with a significant disability. On one end are people who would argue that Down syndrome is not a disability but a mere "difference," and on the other those who consider it such a calamity as to assume that such a child is better off "not born". For example, in India and China, being female is widely considered such a negatively valued human difference that female infanticide occurs such to severely affect the proportion of sexes.
Common human variationsEdit
|Type of Variation||Example|
|Skin Color||Human skin color|
|Eye Color||Eye color|
|Hair Color||Human hair color|
|Hair Quantity||Hair loss|
|Extra Body Parts||Polydactyly|
|Missing Body Parts||Amelia (birth defect)|
|Recessive Phenotypes||Cleft lip and cleft palate|
|Type of Variation||Example|
|Genetic/Longterm Diseases||Sickle-cell disease|
|Type of Variation||Example|
|Type of Variation||Example|
|Type of Variation||Example|
|Developmental Disorders||Progeroid syndromes|
|Type of Variation||Example|
|Temperament||Extraversion and introversion|
- Genetic disease
- Population genetics
- Genomic imprinting
- Human genetic variation
- Ableism / disablism
- Human physical appearance
- High-altitude adaptation
- Effects of high altitude on humans
- List of cutaneous conditions
- "Human variation -- an introduction by The Linux Information Project (LINFO)". www.linfo.org. Retrieved 2016-11-14.
- "Human Skin Color Variation | The Smithsonian Institution's Human Origins Program". humanorigins.si.edu. Retrieved 2016-11-16.
- Tseng, Chin-Hsiao (2005-01-01). "Blackfoot disease and arsenic: a never-ending story". Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews. 23 (1): 55–74. doi:10.1081/GNC-200051860. ISSN 1059-0501. PMID 16291522.
- "STD Facts - Syphilis". www.cdc.gov. Retrieved 2016-11-16.
- "Endocrine Disruptors". www.niehs.nih.gov. Retrieved 2016-11-16.
- Bertoli, Simona; Leone, Alessandro; Battezzati, Alberto (2015-07-01). "Human Bisphenol A Exposure and the "Diabesity Phenotype"". Dose-Response. 13 (3): 1559325815599173. doi:10.1177/1559325815599173. ISSN 1559-3258. PMC . PMID 26858585.
- "Mother's diet modifies her child's DNA | London School of Hygiene & Tropical Medicine | LSHTM". www.lshtm.ac.uk. Retrieved 2016-11-16.
- Jorde, Lynn (16 October 2003). "Genetic Variation and Human Evolution" (PDF). Retrieved 15 November 2016.
- "genetics". Encyclopædia Britannica. Retrieved 2016-11-16.
- "Is eye color determined by genetics". Genetics Home Reference. Retrieved 15 November 2016.
- Reference, Genetics Home. "cystic fibrosis". Genetics Home Reference. Retrieved 2016-11-16.
- "What is a genetic mutation and how do mutations occur?". Genetics Home Reference. National Institutes of Health. Retrieved 15 November 2016.
- Feinberg, Andrew (2007). "Phenotypic plasticity and the epigenetics of human disease". Nature. 447: 433–440. Bibcode:2007Natur.447..433F. doi:10.1038/nature05919.
- Jaenisch, Rudolf; Bird, Adrian (2003). "Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals". Nature Genetics. 33: 245–254. doi:10.1038/ng1089. PMID 12610534.
- Isea, Raúl (30 January 2015). "The Present-Day Meaning Of The Word Bioinformatics" (PDF). Global Journal of Advanced Research. 2 (1): 70–73. Retrieved 16 November 2016.
- Department of Health and Human Services
- "What is Anthropology?". American Anthropological Association. Retrieved 10 November 2016.
- Macy, Michael W.; Willer, Robert (2002). "From Factors to Actors: Computational Sociology and Agent-Based Modeling". Annual Review of Sociology. 28: 143–166. doi:10.1146/annurev.soc.28.110601.141117. JSTOR 3069238.
- "CDC - Anthropometry - NIOSH Workplace Safety and Health Topic". www.cdc.gov. Retrieved 2016-11-16.
- Visscher, Peter M. (2008-05-01). "Sizing up human height variation". Nature Genetics. 40 (5): 489–490. doi:10.1038/ng0508-489. ISSN 1061-4036.
- Jain A.; Hong L.; Pankanti S. (2000). "Biometric Identification" (PDF). Communications of the ACM. 43 (2): 91–98. doi:10.1145/328236.328110.
- "Economic Impact of the Human Genome Project – Battelle" (PDF). Retrieved 1 August 2013.
- Chial, Heidi (2008). "DNA sequencing technologies key to the Human Genome Project". Nature Education. 1 (1). Retrieved 16 November 2016.
- Ring HZ, Kwok PY, Cotton RG (October 2006). "Human Variome Project: an international collaboration to catalogue human genetic variation". Pharmacogenomics. 7 (7): 969–72. doi:10.2217/14622418.104.22.1689. PMID 17054407.
- "random genetic drift / genetic drift | Learn Science at Scitable". www.nature.com. Retrieved 2016-11-16.
- "Genetic drift". evolution.berkeley.edu. Retrieved 2016-11-16.
- Hartl & Clark 2007, p. 112
- Tian 2008, p. 11
- Hedrick 2005, p. 315
- Charlesworth, Brian (March 2009). "Fundamental concepts in genetics: Effective population size and patterns of molecular evolution and variation". Nature Reviews Genetics. London: Nature Publishing Group. 10 (3): 195–205. doi:10.1038/nrg2526. ISSN 1471-0056. PMID 19204717.
- Reference, Genetics Home. "What are single nucleotide polymorphisms (SNPs)?". Genetics Home Reference. Retrieved 2016-11-16.
- Wolf, A. B.; Caselli, R. J.; Reiman, E. M.; Valla, J. (2012). "APOE and neuroenergetics: An emerging paradigm in Alzheimer's disease". Neurobiology of Aging. 34 (4): 1007–17. doi:10.1016/j.neurobiolaging.2012.10.011. PMID 23159550.
- Sebeok, Thomas Albert; Danesi, Marcel (2000-01-01). The Forms of Meaning: Modeling Systems Theory and Semiotic Analysis. Walter de Gruyter. ISBN 9783110167511.
- "NIJ Journal Issue No. 256, January 2007 | National Institute of Justice". National Institute of Justice. Retrieved 2016-11-16.
- Yokobori, Shin-ichi; Suzuki, Tsutomu; Watanabe, Kimitsuna. "Genetic Code Variations in Mitochondria: tRNA as a Major Determinant of Genetic Code Plasticity". Journal of Molecular Evolution. 53 (4–5): 314–326. Bibcode:2001JMolE..53..314Y. doi:10.1007/s002390010221. ISSN 0022-2844. PMID 11675591.
- "United Nations Principles and Recommendations for Population and Housing Censuses" (PDF). Retrieved 16 November 2016.
- McQuarrie, Edward F. (2006). The market research toolbox : a concise guide for beginners (2nd ed.). Thousand Oaks, Calif.: Sage Publications. ISBN 978-1-4129-1319-5.
- Luzzatto, Lucio (3 October 2012). "Sickle Cell Anaemia and Malaria". Mediterranean Journal of Hematology and Infectious Diseases. 4: e2012065. doi:10.4084/MJHID.2012.065. PMC . PMID 23170194.
- "Dropping birth rates threaten global economic growth". CBS. 2014-05-07. Retrieved 2016-11-13.
- "Tall women more likely to have twins". livescience.
- "Taller Women Are More Likely To Have Twins, Obstetrician's Study Confirms".
- "Homosexuality". pbs.org.
- Clayton, Victoria (2007-03-09). "To cut or not? Circumcision controversy flares". NBC News. Retrieved 2016-11-13.
- Adams, Tim (2016-11-13). "Transgender children: the parents and doctors on the frontline". The Guardian. ISSN 0261-3077. Retrieved 2016-11-13.
- DeLamater, John D.; Hyde, Janet Shibley (1998). "Essentialism vs. Social Constructionism in the Study of Human Sexuality" (PDF). The Journal of Sex Research. 35 (1): 10–18. doi:10.1080/00224499809551913. JSTOR 3813161.
- Jha, Rupa (2014-10-27). "100 Women 2014: The taboo of menstruating in India". BBC News. Retrieved 2016-11-13.
- "Nazi Racism". www.ushmm.org. United States Holocaust Memorial Museum. Retrieved 2016-11-14.
- "Ethics Guide: Female infanticide". BBC. BBC. Retrieved 2016-11-14.
- Tian, Jianjun Paul (2008). Evolution Algebras and their Applications. Lecture Notes in Mathematics. 1921. Berlin; New York: Springer. doi:10.1007/978-3-540-74284-5. ISBN 978-3-540-74283-8. LCCN 2007933498. OCLC 173807298. Zbl 1136.17001.
- Hedrick, Philip W. (2005). Genetics of Populations (3rd ed.). Boston, MA: Jones and Bartlett Publishers. ISBN 0-7637-4772-6. LCCN 2004056666. OCLC 56194719.