Scinderin (also known as adseverin) is a protein that in humans is encoded by the SCIN gene.[5] Scinderin is an actin severing protein belonging to the gelsolin superfamily.[6] It was discovered in Dr. Trifaro's laboratory at the University of Ottawa, Canada. Secretory tissues are rich in scinderin. In these tissues scinderin, a calcium dependent protein, regulates cortical actin networks. Normally secretory vesicles are excluded from release sites on the plasma membrane by the presence of a cortical actin filament network. During cell stimulation, calcium channels open allowing calcium ions to enter the secretory cell. Increase in intracellular calcium activates scinderin with the consequent actin filament severing and local dissociation of actin filament networks. This allows the movement of secretory vesicles to release sites on the plasma membrane.

SCIN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSCIN, scinderin
External IDsOMIM: 613416; MGI: 1306794; HomoloGene: 36296; GeneCards: SCIN; OMA:SCIN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001112706
NM_033128

NM_001146196
NM_009132

RefSeq (protein)

NP_001106177
NP_149119

NP_001139668
NP_033158

Location (UCSC)Chr 7: 12.57 – 12.66 MbChr 12: 40.11 – 40.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000006747Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002565Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SCIN scinderin".
  6. ^ Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

Further reading

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