The "Actinobacteria" are a phylum of mostly Gram-positive bacteria. They can be terrestrial or aquatic. They are of great economic importance to humans because agriculture and forests depend on their contributions to soil systems. In soil they help to decompose the organic matter of dead organisms so the molecules can be taken up anew by plants. While this role is also played by fungi, Actinobacteria are much smaller and likely do not occupy the same ecological niche. In this role the colonies often grow extensive mycelia, like a fungus would, and the name of an important order of the phylum, Actinomycetales (the actinomycetes), reflects that they were long believed to be fungi. Some soil actinobacteria (such as Frankia) live symbiotically with the plants whose roots pervade the soil, fixing nitrogen for the plants in exchange for access to some of the plant's saccharides. Other species, such as many members of the genus Mycobacterium, are important pathogens.
|Scanning electron micrograph of Actinomyces israelii.|
Beyond the great interest in "Actinobacteria" for their soil role, much is yet to be learned about them. Although currently understood primarily as soil bacteria, they might be more abundant in fresh waters. "Actinobacteria" is one of the dominant bacterial phyla and contains one of the largest of bacterial genera, Streptomyces. Streptomyces and other actinobacteria are major contributors to biological buffering of soils. They are also the source of many antibiotics.
The "Actinobateria" genus Bifidobacterium is the most common bacterium in the microbiome of human infants. Although adults have fewer bifidobacteria, intestinal bifidobacteria help maintain the mucosal barrier and reduce lipopolysaccharide in the intestine.
Although some of the largest and most complex bacterial cells belong to the "Actinobacteria", the group of marine Actinomarinales has been described as possessing the smallest free-living prokaryotic cells.
Some Siberian or Antarctic "Actinobacteria" is said to be the oldest living organism on Earth, frozen in permafrost at around half a million years ago. The symptoms of life were detected by CO
2 release from permafrost samples 640 kya or younger. 
Most "Actinobacteria" of medical or economic significance are in class Actinobacteria, and belong to the order Actinomycetales. While many of these cause disease in humans, Streptomyces is notable as a source of antibiotics.
Of those "Actinobacteria" not in the Actinomycetales, Gardnerella is one of the most researched. Classification of Gardnerella is controversial, and MeSH catalogues it as both a Gram-positive and Gram-negative organism.
"Actinobacteria", especially Streptomyces spp., are recognized as the producers of many bioactive metabolites that are useful to humans in medicine, such as antibacterials, antifungals, antivirals, antithrombotics, immunomodifiers, antitumor drugs, and enzyme inhibitors; and in agriculture, including insecticides, herbicides, fungicides, and growth-promoting substances for plants and animals. "Actinobacteria"-derived antibiotics that are important in medicine include aminoglycosides, anthracyclines, chloramphenicol, macrolide, tetracyclines, etc.
The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN). The phylogeny is based on whole-genome analysis.
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