Acetoxycycloheximide is an organic chemical compound. It can be considered as the acetylated analogue of cycloheximide. It is a potent protein synthesis inhibitor in animal cells[1] and can inhibit the formation of memories.[2][3]
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| IUPAC name
(1R,3S,5S)-3-[(1R)-2-(2,6-Dioxo-4-piperidinyl)-1-hydroxyethyl]-1,5-dimethyl-4-oxocyclohexyl acetate
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| Other names
Acetyloxycycloheximide
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C17H25NO6 | |
| Molar mass | 339.388 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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See also edit
References edit
- ^ Mahy, Brian W J (2001). A dictionary of virology (3. ed.). San Diego, Calif. [u.a.]: Academic Press. pp. 2. ISBN 0-12-465327-8.
- ^ Flood, James F.; Bennett, Edward L.; Orme, Ann E.; Rosenzweig, Mark R. (February 1975). "Effects of protein synthesis inhibition on memory for active avoidance training" (PDF). Physiology & Behavior. 14 (2): 177–184. doi:10.1016/0031-9384(75)90163-8. PMID 1161822. S2CID 31577844.
- ^ Flexner, L. B.; Flexner, J. B.; Roberts, R. B. (1 August 1966). "Stages of memory in mice treated with acetoxycycloheximide before or immediately after learning". Proceedings of the National Academy of Sciences. 56 (2): 730–735. Bibcode:1966PNAS...56..730F. doi:10.1073/pnas.56.2.730. PMC 224433. PMID 5229991.