Acantholepis is the scientific name of several genera of organisms. It may refer to:

  • Echinops, a genus of plants; synonym Acantholepis (Less.)
  • Argentina, a genus of fish; synonym Acantholepis (Krøyer, 1846)
  • Lepisiota, a genus of ants; synonym Acantholepis (Mayr, 1861)
  • Eczematolepis, an extinct genus of ptyctodontidan