Autophagy-related protein 9A is a protein that in humans is encoded by the ATG9A gene.[5]

ATG9A
Identifiers
AliasesATG9A, APG9L1, MGD3208, mATG9, autophagy related 9A
External IDsOMIM: 612204; MGI: 2138446; HomoloGene: 34495; GeneCards: ATG9A; OMA:ATG9A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001077198
NM_024085

NM_001003917
NM_001288612
NM_001288613

RefSeq (protein)

NP_001070666
NP_076990
NP_001070666.1
NP_076990.4

Location (UCSC)Chr 2: 219.22 – 219.23 MbChr 1: 75.16 – 75.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Functional studies indicate that ATG9A plays a role in autophagy.[6][7] and other non-autophagy membrane remodeling processes such as plasma membrane repair.[8] Enzymatically, it is a lipid scramblase.[6][7] ATG9A interacts with IQGAP1 and the ESCRT machinery in membrane remodeling.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198925Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033124Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae)".
  6. ^ a b Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, et al. (December 2020). "Structure, lipid scrambling activity and role in autophagosome formation of ATG9A". Nature Structural & Molecular Biology. 27 (12): 1194–1201. doi:10.1038/s41594-020-00520-2. PMC 7718406. PMID 33106659.
  7. ^ a b Matoba K, Kotani T, Tsutsumi A, Tsuji T, Mori T, Noshiro D, et al. (December 2020). "Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion". Nature Structural & Molecular Biology. 27 (12): 1185–1193. doi:10.1038/s41594-020-00518-w. PMID 33106658. S2CID 225081989.
  8. ^ a b Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GP, et al. (July 2021). "ATG9A protects the plasma membrane from programmed and incidental permeabilization". Nature Cell Biology. 23 (8): 846–858. doi:10.1038/s41556-021-00706-w. ISSN 1465-7392. PMC 8276549. PMID 34257406.

Further reading

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