Activating transcription factor 7-interacting protein 1 is a protein that in humans is encoded by the ATF7IP gene.[5][6][7]

ATF7IP
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesATF7IP, AM, ATF-IP, MCAF, MCAF1, p621, activating transcription factor 7 interacting protein
External IDsOMIM: 613644; MGI: 1858965; HomoloGene: 10051; GeneCards: ATF7IP; OMA:ATF7IP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001286514
NM_001286515
NM_018179
NM_181352

NM_019426

RefSeq (protein)

NP_001273443
NP_001273444
NP_060649
NP_851997
NP_060649.3

NP_062299
NP_001375123
NP_001375124
NP_001375125
NP_001375126

Location (UCSC)Chr 12: 14.37 – 14.5 MbChr 6: 136.51 – 136.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

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ATF7IP has been shown to interact with MBD1.[8] In mice with T cell-specific deletion of Atf7ip, the protein has been shown to play a role in regulating T helper 17 cell (Th17) differentiation due to increased IL-2 production upon stimulation of the T cell receptor (TCR). This TCR stimulation occurs through deposition of H3K9me3, a repressive histone mark.[9][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171681Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030213Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gunther M, Laithier M, Brison O (Dec 2000). "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol Cell Biochem. 210 (1–2): 131–42. doi:10.1023/A:1007177623283. PMID 10976766. S2CID 1339642.
  6. ^ De Graeve F, Bahr A, Chatton B, Kedinger C (Jun 2000). "A murine ATFa-associated factor with transcriptional repressing activity". Oncogene. 19 (14): 1807–19. doi:10.1038/sj.onc.1203492. PMID 10777215. S2CID 22900736.
  7. ^ "Entrez Gene: ATF7IP activating transcription factor 7 interacting protein".
  8. ^ Fujita, Naoyuki; Watanabe Sugiko; Ichimura Takaya; Ohkuma Yoshiaki; Chiba Tsutomu; Saya Hideyuki; Nakao Mitsuyoshi (Apr 2003). "MCAF Mediates MBD1-Dependent Transcriptional Repression". Mol. Cell. Biol. 23 (8). United States: 2834–43. doi:10.1128/MCB.23.8.2834-2843.2003. ISSN 0270-7306. PMC 152570. PMID 12665582.
  9. ^ Sin, Jun Hyung; Zuckerman, Cassandra; Cortez, Jessica T.; Eckalbar, Walter L.; Erle, David J.; Anderson, Mark S.; Waterfield, Michael R. (2019-09-02). "The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses". The Journal of Experimental Medicine. 216 (9): 2024–2037. doi:10.1084/jem.20182316. ISSN 1540-9538. PMC 6719416. PMID 31217192.
  10. ^ Zhao, Zhipeng; Feng, Lu; Peng, Xuerun; Ma, Tingnan; Tong, Rongsheng; Zhong, Lei (2022). "Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response". Frontiers in Pharmacology. 13: 1073713. doi:10.3389/fphar.2022.1073713. ISSN 1663-9812. PMC 9793902. PMID 36582533.

Further reading

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  • Human ATF7IP genome location and ATF7IP gene details page in the UCSC Genome Browser.
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Activating transcription factor 7-interacting protein 1 (ATF7IP)