ARNT2

Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene.

ARNT2
Identifiers
Aliases	ARNT2, WEDAS, bHLHe1, aryl hydrocarbon receptor nuclear translocator 2
External IDs	OMIM: 606036; MGI: 107188; HomoloGene: 7230; GeneCards: ARNT2; OMA:ARNT2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q25.1 Start 80,404,350 bp End 80,597,933 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 D3|7 48.35 cM Start 83,895,486 bp End 84,059,384 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus middle temporal gyrus frontal pole middle frontal gyrus Brodmann area 10 entorhinal cortex optic nerve superior vestibular nucleus parietal lobe ventral tegmental area Top expressed in subiculum superior frontal gyrus paraventricular nucleus of hypothalamus globus pallidus nucleus accumbens dorsal tegmental nucleus dorsomedial hypothalamic nucleus ganglionic eminence ventral tegmental area dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein dimerization activity DNA-binding transcription factor activity aryl hydrocarbon receptor binding DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm transcription regulator complex nucleus nucleoplasm Biological process response to estradiol response to hypoxia regulation of transcription, DNA-templated negative regulation of apoptotic process in utero embryonic development transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription, DNA-templated central nervous system development brain development positive regulation of cell population proliferation xenobiotic metabolic process positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9915 11864 Ensembl ENSG00000172379 ENSMUSG00000015709 UniProt Q9HBZ2 Q61324 RefSeq (mRNA) NM_014862 NM_007488 RefSeq (protein) NP_055677 NP_055677.3 NP_031514 Location (UCSC) Chr 15: 80.4 – 80.6 Mb Chr 7: 83.9 – 84.06 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively.

External links

• Human ARNT2 genome location and ARNT2 gene details page in the UCSC Genome Browser.

Further reading

• Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Moffett P, Pelletier J (2000). "Different transcriptional properties of mSim-1 and mSim-2". FEBS Lett. 466 (1): 80–6. doi:10.1016/S0014-5793(99)01750-0. PMID 10648817. S2CID 30972686.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Barrow LL, Wines ME, Romitti PA, et al. (2003). "Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for human orofacial clefts". Teratology. 66 (2): 85–90. doi:10.1002/tera.10062. PMID 12210012.
• Stolze I, Berchner-Pfannschmidt U, Freitag P, et al. (2002). "Hypoxia-inducible erythropoietin gene expression in human neuroblastoma cells". Blood. 100 (7): 2623–8. doi:10.1182/blood-2001-12-0169. PMID 12239177.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ooe N, Saito K, Mikami N, et al. (2004). "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression". Mol. Cell. Biol. 24 (2): 608–16. doi:10.1128/MCB.24.2.608-616.2004. PMC 343817. PMID 14701734.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Friedman ER, Fan CM (2007). "Separate necdin domains bind ARNT2 and HIF1alpha and repress transcription". Biochem. Biophys. Res. Commun. 363 (1): 113–8. doi:10.1016/j.bbrc.2007.08.108. PMC 2083645. PMID 17826745.