Rho guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the ARHGEF5 gene.[5][6][7]

ARHGEF5
Identifiers
AliasesARHGEF5, GEF5, P60, TIM, TIM1, Rho guanine nucleotide exchange factor 5
External IDsOMIM: 600888; MGI: 1858952; HomoloGene: 66300; GeneCards: ARHGEF5; OMA:ARHGEF5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001002861
NM_005435

NM_133674

RefSeq (protein)

NP_005426

NP_598435

Location (UCSC)Chr 7: 144.36 – 144.38 MbChr 6: 43.24 – 43.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000050327Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033542Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chan AM, McGovern ES, Catalano G, Fleming TP, Miki T (Apr 1994). "Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins". Oncogene. 9 (4): 1057–63. PMID 8134109.
  6. ^ Takai S, Chan AM, Yamada K, Miki T (Oct 1995). "Assignment of the human TIM proto-oncogene to 7q33→q35". Cancer Genet Cytogenet. 83 (1): 87–9. doi:10.1016/S0165-4608(95)00017-8. PMID 7656213.
  7. ^ a b "Entrez Gene: ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5".
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Further reading

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