ADP-ribosylation factor GTPase-activating protein 3 is a protein that in humans is encoded by the ARFGAP3 gene.[5][6][7]

ARFGAP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesARFGAP3, ARFGAP1, ADP ribosylation factor GTPase activating protein 3
External IDsOMIM: 612439; MGI: 1913501; HomoloGene: 134103; GeneCards: ARFGAP3; OMA:ARFGAP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142293
NM_014570

NM_025445
NM_001357756
NM_001357757

RefSeq (protein)

NP_001135765
NP_055385

NP_079721
NP_001344685
NP_001344686

Location (UCSC)Chr 22: 42.8 – 42.86 MbChr 15: 83.18 – 83.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which is thought to interact with ADP-ribosylation factor 1 (ARF1). The encoded protein likely promotes hydrolysis of ARF1-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000242247Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054277Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhang C, Yu Y, Zhang S, Liu M, Xing G, Wei H, Bi J, Liu X, Zhou G, Dong C, Hu Z, Zhang Y, Luo L, Wu C, Zhao S, He F (Jul 2000). "Characterization, chromosomal assignment, and tissue expression of a novel human gene belonging to the ARF GAP family". Genomics. 63 (3): 400–8. doi:10.1006/geno.1999.6095. PMID 10704287.
  6. ^ Liu X, Zhang C, Xing G, Chen Q, He F (Feb 2001). "Functional characterization of novel human ARFGAP3". FEBS Lett. 490 (1–2): 79–83. doi:10.1016/S0014-5793(01)02134-2. PMID 11172815. S2CID 34808599.
  7. ^ a b "Entrez Gene: ARFGAP3 ADP-ribosylation factor GTPase activating protein 3".
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Further reading

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