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Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.[5]

APOA2
Protein APOA2 PDB 1l6l.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPOA2, Apo-AII, ApoA-II, apoAII, Apolipoprotein A2
External IDsMGI: 88050 HomoloGene: 1242 GeneCards: APOA2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for APOA2
Genomic location for APOA2
Band1q23.3Start161,222,292 bp[1]
End161,223,631 bp[1]
RNA expression pattern
PBB GE APOA2 219465 at fs.png

PBB GE APOA2 219466 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001643

NM_013474
NM_001305549
NM_001305550
NM_001305585

RefSeq (protein)

NP_001634

NP_001292478
NP_001292479
NP_001292514
NP_038502

Location (UCSC)Chr 1: 161.22 – 161.22 MbChr 1: 171.23 – 171.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
ApoA-II
PDB 1l6l EBI.jpg
structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions
Identifiers
SymbolApoA-II
PfamPF04711
InterProIPR006801
SCOPe1l6k / SUPFAM

Contents

FunctionEdit

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia.[6]

InteractionsEdit

APOA2 has been shown to interact with PLTP.[7]

Interactive pathway mapEdit

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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|px|alt=Statin Pathway edit]]
Statin Pathway edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158874 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005681 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Tsao YK, Wei CF, Robberson DL, Gotto AM, Chan L (Dec 1985). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". The Journal of Biological Chemistry. 260 (28): 15222–31. PMID 2415515.
  6. ^ "Entrez Gene: APOA2 apolipoprotein A-II".
  7. ^ Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". Journal of Lipid Research. 39 (1): 152–61. PMID 9469594.

External linksEdit

Further readingEdit