Annexin A4

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Annexin A4 is a protein that in humans is encoded by the ANXA4 gene.[5][6]

ANXA4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANXA4, ANX4, HEL-S-274, PIG28, ZAP36, P32.5, PAP-II, PP4-X, annexin A4
External IDsOMIM: 106491; MGI: 88030; HomoloGene: 68164; GeneCards: ANXA4; OMA:ANXA4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001153
NM_001320698
NM_001320700
NM_001320702
NM_001365496

NM_013471
NM_001331120

RefSeq (protein)

NP_001144
NP_001307627
NP_001307629
NP_001307631
NP_001352425

NP_001318049
NP_038499

Location (UCSC)Chr 2: 69.64 – 69.83 MbChr 6: 86.71 – 86.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196975Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029994Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tait JF, Smith C, Frankenberry DA, Miao CH, Adler DA, Disteche CM (Feb 1992). "Chromosomal mapping of the human annexin IV (ANX4) gene". Genomics. 12 (2): 313–8. doi:10.1016/0888-7543(92)90379-7. PMID 1346776.
  6. ^ a b "Entrez Gene: ANXA4 annexin A4".
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Further reading

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