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Aldehyde dehydrogenase 9 family, member A1

  (Redirected from ALDH9A1)

4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.[5][6][7]

ALDH9A1
Identifiers
AliasesALDH9A1, ALDH4, ALDH7, ALDH9, E3, TMABADH, aldehyde dehydrogenase 9 family member A1
External IDsMGI: 1861622 HomoloGene: 55483 GeneCards: ALDH9A1
EC number1.2.1.3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ALDH9A1
Genomic location for ALDH9A1
Band1q24.1Start165,662,216 bp[1]
End165,698,863 bp[1]
RNA expression pattern
PBB GE ALDH9A1 201612 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000696
NM_001365774

NM_019993

RefSeq (protein)

NP_000687
NP_001352703

NP_064377

Location (UCSC)Chr 1: 165.66 – 165.7 MbChr 1: 167.35 – 167.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Contents

FunctionEdit

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.[7]

ReferencesEdit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143149 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026687 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (February 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Human Genetics. 93 (2): 211–2. doi:10.1007/bf00210615. PMID 8112751.
  6. ^ Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (June 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression". Genomics. 34 (3): 376–80. doi:10.1006/geno.1996.0300. PMID 8786138.
  7. ^ a b "Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1".

External linksEdit

Further readingEdit

  • Kurys G, Ambroziak W, Pietruszko R (March 1989). "Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde". The Journal of Biological Chemistry. 264 (8): 4715–21. PMID 2925663.
  • Kurys G, Shah PC, Kikonygo A, Reed D, Ambroziak W, Pietruszko R (December 1993). "Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde". European Journal of Biochemistry. 218 (2): 311–20. doi:10.1111/j.1432-1033.1993.tb18379.x. PMID 8269919.
  • Kikonyogo A, Pietruszko R (May 1996). "Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution". The Biochemical Journal. 316 ( Pt 1) (1): 317–24. PMC 1217341. PMID 8645224.
  • Izaguirre G, Kikonyogo A, Pietruszko R (September 1997). "Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 118 (1): 59–64. doi:10.1016/s0305-0491(97)00022-9. PMID 9417993.
  • Vaz FM, Fouchier SW, Ofman R, Sommer M, Wanders RJ (March 2000). "Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis". The Journal of Biological Chemistry. 275 (10): 7390–4. doi:10.1074/jbc.275.10.7390. PMID 10702312.
  • Izaguirre G, Pietruszko R, Cho S, MacKerell A (December 2001). "Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs". Journal of Biomolecular Structure & Dynamics. 19 (3): 429–47. doi:10.1080/07391102.2001.10506752. PMID 11790142.