ADB-5'Br-BUTINACA

ADB-5'Br-BUTINACA
Identifiers
	IUPAC name N-[(2S)-1-amino-3,3-dimethyl-1-oxobutan-2-yl]-5-bromo-1-butylindazole-3-carboxamide;
PubChem CID	168322646;
ChemSpider	115005697;
Chemical and physical data
Formula	C18H25BrN4O2
Molar mass	409.328 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES NC(=O)[C@@H](NC(=O)c1nn(CCCC)c2ccc(Br)cc21)C(C)(C)C;
	InChI InChI=1S/C18H25BrN4O2/c1-5-6-9-23-13-8-7-11(19)10-12(13)14(22-23)17(25)21-15(16(20)24)18(2,3)4/h7-8,10,15H,5-6,9H2,1-4H3,(H2,20,24)(H,21,25)/t15-/m1/s1; Key:DIOILIVJIIJFPO-OAHLLOKOSA-N;

ADB-5'Br-BUTINACA (ADB-B-5Br-INACA) is an indazole-3-carboxamide based synthetic cannabinoid receptor agonist which has been sold as a designer drug,^[1] first detected in Philadelphia in the US in May 2022,^[2] and subsequently found in South Korea,^[3] Portugal and Sweden.^[4] It is specifically listed as an illegal drug in Italy,^[5] South Korea^[6] and several states in the US,^[7]^[8] and controlled under analogue legislation in various other jurisdictions.

References

^ Deventer MH, Persson M, Norman C, Liu H, Connolly MJ, Daéid NN, McKenzie C, Gréen H, Stove CP (October 2023). "In vitro cannabinoid activity profiling of generic ban-evading brominated synthetic cannabinoid receptor agonists and their analogs". Drug Testing and Analysis. doi:10.1002/dta.3592. PMID 37903509. S2CID 264671035.
^ "ADB-5'Br-BINACA" (PDF). CFSRE Chemistry Report. The Center for Forensic Science Research & Education.
^ Kim J, Yum H, Kang S, Lee N, Song J, Park Y, Choe S, Park M (November 2023). "Comprehensive evaluation of drug cases in Seoul and its metropolitan areas - 2022". Forensic Science International. 353: 111877. doi:10.1016/j.forsciint.2023.111877. PMID 37989071. S2CID 265022768.
^ "Yttrande enligt 13 § Lag (2011:111) om förstörande av vissa hälsofarliga missbrukssubstanser" [Opinion according to § 13 Act (2011:111) on the destruction of certain substances of abuse dangerous to health] (PDF) (in Swedish). The Public Health Authority.
^ "Aggiornamento delle tabelle contenenti l'indicazione delle sostanze stupefacenti e psicotrope, di cui al decreto del Presidente della Repubblica 9 ottobre 1990, n. 309 e successive modificazioni e integrazioni. Inserimento nella Tabella I di nuove sostanze psicoattive. (23A01072)" [Update of the tables containing the indication of the substances narcotic and psychotropic drugs, referred to in the decree of the President of the Republic 9 October 1990, n. 309 and subsequent amendments e integrations. Inclusion of new substances in Table I psychoactive. (23A01072)] (in Italian). Italy: Ministry of Health. 13 February 2023.
^ "˝에이디비-5'비알-부티나카˝ 등 3종 임시마약류 지정예고" [Announcement of temporary designation of 3 types of narcotics, including “ADB-5 ‘BR-Butinaka’”]. Korean Food and Drug Daily News (in Korean).
^ "18VAC110-20-322. Placement of chemicals in Schedule I." Administrative Code. Commonwealth of Virginia.
^ "Section 19-03.1-05 - Schedule I, N.D. Cent. Code § 19-03.1-05". North Dakota Century Code.

[pmid37903509-1] Deventer MH, Persson M, Norman C, Liu H, Connolly MJ, Daéid NN, McKenzie C, Gréen H, Stove CP (October 2023). "In vitro cannabinoid activity profiling of generic ban-evading brominated synthetic cannabinoid receptor agonists and their analogs". Drug Testing and Analysis. doi:10.1002/dta.3592. PMID 37903509. S2CID 264671035.

[2] "ADB-5'Br-BINACA" (PDF). CFSRE Chemistry Report. The Center for Forensic Science Research & Education.

[pmid37989071-3] Kim J, Yum H, Kang S, Lee N, Song J, Park Y, Choe S, Park M (November 2023). "Comprehensive evaluation of drug cases in Seoul and its metropolitan areas - 2022". Forensic Science International. 353: 111877. doi:10.1016/j.forsciint.2023.111877. PMID 37989071. S2CID 265022768.

[4] "Yttrande enligt 13 § Lag (2011:111) om förstörande av vissa hälsofarliga missbrukssubstanser" [Opinion according to § 13 Act (2011:111) on the destruction of certain substances of abuse dangerous to health] (PDF) (in Swedish). The Public Health Authority.

[5] "Aggiornamento delle tabelle contenenti l'indicazione delle sostanze stupefacenti e psicotrope, di cui al decreto del Presidente della Repubblica 9 ottobre 1990, n. 309 e successive modificazioni e integrazioni. Inserimento nella Tabella I di nuove sostanze psicoattive. (23A01072)" [Update of the tables containing the indication of the substances narcotic and psychotropic drugs, referred to in the decree of the President of the Republic 9 October 1990, n. 309 and subsequent amendments e integrations. Inclusion of new substances in Table I psychoactive. (23A01072)] (in Italian). Italy: Ministry of Health. 13 February 2023.

[6] "˝에이디비-5'비알-부티나카˝ 등 3종 임시마약류 지정예고" [Announcement of temporary designation of 3 types of narcotics, including “ADB-5 ‘BR-Butinaka’”]. Korean Food and Drug Daily News (in Korean).

[7] "18VAC110-20-322. Placement of chemicals in Schedule I." Administrative Code. Commonwealth of Virginia.

[8] "Section 19-03.1-05 - Schedule I, N.D. Cent. Code § 19-03.1-05". North Dakota Century Code.

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Identifiers

IUPAC name N-[(2S)-1-amino-3,3-dimethyl-1-oxobutan-2-yl]-5-bromo-1-butylindazole-3-carboxamide
PubChem CID	168322646
ChemSpider	115005697
Chemical and physical data
Formula	C₁₈H₂₅BrN₄O₂
Molar mass	409.328 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES NC(=O)[C@@H](NC(=O)c1nn(CCCC)c2ccc(Br)cc21)C(C)(C)C
InChI InChI=1S/C18H25BrN4O2/c1-5-6-9-23-13-8-7-11(19)10-12(13)14(22-23)17(25)21-15(16(20)24)18(2,3)4/h7-8,10,15H,5-6,9H2,1-4H3,(H2,20,24)(H,21,25)/t15-/m1/s1 Key:DIOILIVJIIJFPO-OAHLLOKOSA-N

ADB-5'Br-BUTINACA

See also

References