A disintegrin and metalloproteinase with thrombospondin motifs 12 is an enzyme that in humans is encoded by the ADAMTS12 gene.[5]

ADAMTS12
Identifiers
AliasesADAMTS12, PRO4389, ADAM metallopeptidase with thrombospondin type 1 motif 12
External IDsOMIM: 606184; MGI: 2146046; HomoloGene: 12808; GeneCards: ADAMTS12; OMA:ADAMTS12 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030955
NM_001324511
NM_001324512

NM_175501

RefSeq (protein)

NP_001311440
NP_001311441
NP_112217

NP_780710

Location (UCSC)Chr 5: 33.52 – 33.89 MbChr 15: 11.06 – 11.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion.[5]

References

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  1. ^ a b c ENSG00000281690 GRCh38: Ensembl release 89: ENSG00000151388, ENSG00000281690Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047497Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12".

Further reading

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