A63 or A-63 may refer to:
- A63 road, a road in England connecting Leeds and Hull
- A63 motorway (France), a road connecting Bordeaux and the border with Spain
- A63 motorway (Germany), a road connecting Mainz and Kaiserslautern
- A63 motorway (Spain), a road connecting Oviedo and Canero
- Encyclopaedia of Chess Openings code for the Benoni Defense
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