A. grandis may refer to:
- Abies grandis, the grand fir, giant fir, lowland white fir, great silver fir, Western white fir, Vancouver fir or Oregon fir, a tree species native to the Pacific Northwest and Northern California of North America
- Aeshna grandis, the brown hawker, a large dragonfly species widespread in England
- Alternanthera grandis, a plant species endemic to Ecuador
- Angistorhinus grandis, an extinct phytosaur species found in Texas and Wyoming in the United States and that lived from the Late Triassic period
- Astelia grandis, a plant species in the genus Astelia native to New Zealand
- Aublysodon grandis, a nomen dubium given to a large number of carnivorous dinosaur teeth
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