6-Hydroxynicotinate 3-monooxygenase

6-Hydroxynicotinate 3-monooxygenase (EC 1.14.13.114, NicC, 6HNA monooxygenase, HNA-3-monooxygenase) is an enzyme with systematic name 6-hydroxynicotinate,NADH:oxygen oxidoreductase (3-hydroxylating, decarboxylating).[1][2] This enzyme catalyses the following chemical reaction

6-Hydroxynicotinate 3-monooxygenase
Identifiers
EC no.1.14.13.114
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins
6-hydroxynicotinate + NADH + H+ + O2 2,5-dihydroxypyridine + NAD+ + H2O + CO2

6-Hydroxynicotinate 3-monooxygenase a flavoprotein (FAD).

References

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  1. ^ Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T (February 1999). "Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5". European Journal of Biochemistry. 260 (1): 120–6. doi:10.1046/j.1432-1327.1999.00124.x. PMID 10091591.
  2. ^ Jiménez JI, Canales A, Jiménez-Barbero J, Ginalski K, Rychlewski L, García JL, Díaz E (August 2008). "Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440". Proceedings of the National Academy of Sciences of the United States of America. 105 (32): 11329–34. Bibcode:2008PNAS..10511329J. doi:10.1073/pnas.0802273105. PMC 2516282. PMID 18678916.
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